MED21

Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.[5][6]

MED21
Identifiers
AliasesMED21, SRB7, SURB7, hSrb7, mediator complex subunit 21
External IDsOMIM: 603800 MGI: 1347064 HomoloGene: 3148 GeneCards: MED21
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p11.23Start27,022,546 bp[1]
End27,066,343 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9412

108098

Ensembl

ENSG00000152944

ENSMUSG00000030291

UniProt

Q13503

Q9CQ39

RefSeq (mRNA)

NM_001271811
NM_004264

NM_025315

RefSeq (protein)

NP_001258740
NP_004255

NP_079591

Location (UCSC)Chr 12: 27.02 – 27.07 MbChr 6: 146.64 – 146.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

MED21 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000152944 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030291 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chao DM, Gadbois EL, Murray PJ, Anderson SF, Sonu MS, Parvin JD, Young RA (Apr 1996). "A mammalian SRB protein associated with an RNA polymerase II holoenzyme". Nature. 380 (6569): 82–5. doi:10.1038/380082a0. PMID 8598913. S2CID 4349547.
  6. "Entrez Gene: SURB7 SRB7 suppressor of RNA polymerase B homolog (yeast)".
  7. Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
  8. Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (Sep 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. PMC 109120. PMID 9710619.
  9. Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (Oct 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. doi:10.1128/MCB.17.10.6029. PMC 232452. PMID 9315662.
  10. Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi:10.1016/s1097-2765(00)80463-3. PMID 10198638.
  11. Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769.
  12. Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D (Aug 1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell. 2 (2): 213–22. doi:10.1016/s1097-2765(00)80131-8. PMID 9734358.

Further reading


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