RGS3

Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene.[5][6][7]

RGS3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRGS3, C2PA, RGP3, regulator of G-protein signaling 3, regulator of G protein signaling 3
External IDsOMIM: 602189 MGI: 1354734 HomoloGene: 32440 GeneCards: RGS3
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q32Start113,444,731 bp[1]
End113,597,743 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5998

50780

Ensembl

ENSG00000138835

ENSMUSG00000059810

UniProt

P49796

Q9DC04

RefSeq (mRNA)

NM_001081650
NM_019492
NM_134257
NM_001310706

RefSeq (protein)

NP_001075119
NP_001297635
NP_062365
NP_599018

Location (UCSC)Chr 9: 113.44 – 113.6 MbChr 4: 62.56 – 62.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000138835 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000059810 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature. 379 (6567): 742–6. doi:10.1038/379742a0. PMID 8602223. S2CID 4362632.
  6. Linares JL, Wendling C, Tomasetto C, Rio MC (Nov 2000). "C2PA, a new protein expressed during mouse spermatogenesis". FEBS Lett. 480 (2–3): 249–54. doi:10.1016/S0014-5793(00)01942-6. PMID 11034339. S2CID 12703563.
  7. "Entrez Gene: RGS3 regulator of G-protein signalling 3".

Further reading

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