USF2

Upstream stimulatory factor 2 is a protein that in humans is encoded by the USF2 gene.[5][6]

USF2
Identifiers
AliasesUSF2, FIP, bHLHb12, upstream transcription factor 2, c-fos interacting
External IDsOMIM: 600390 MGI: 99961 HomoloGene: 2527 GeneCards: USF2
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.12Start35,268,962 bp[1]
End35,279,821 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7392

22282

Ensembl

ENSG00000105698

ENSMUSG00000058239

UniProt

Q15853

Q64705

RefSeq (mRNA)

NM_003367
NM_207291
NM_001321150

NM_011680

RefSeq (protein)

NP_001308079
NP_003358
NP_997174

NP_035810

Location (UCSC)Chr 19: 35.27 – 35.28 MbChr 7: 30.95 – 30.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through Pyridine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

Interactions

USF2 has been shown to interact with USF1 (human gene),[7][8] PPRC1[9] and BRCA1.[10]

Regulation

The USF2 gene is repressed by the microRNA miR-10a.[11]

References

  1. GRCh38: Ensembl release 89: ENSG00000105698 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000058239 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Groenen PM, Garcia E, Debeer P, Devriendt K, Fryns JP, Van de Ven WJ (Dec 1996). "Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia". Genomics. 38 (2): 141–8. doi:10.1006/geno.1996.0609. PMID 8954795.
  6. "Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting".
  7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  8. Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.
  9. Moore ML, Park EA, McMillin JB (May 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". The Journal of Biological Chemistry. 278 (19): 17263–8. doi:10.1074/jbc.M210486200. PMID 12611894.
  10. Cable PL, Wilson CA, Calzone FJ, Rauscher FJ, Scully R, Livingston DM, Li L, Blackwell CB, Futreal PA, Afshari CA (Oct 2003). "Novel consensus DNA-binding sequence for BRCA1 protein complexes". Molecular Carcinogenesis. 38 (2): 85–96. doi:10.1002/mc.10148. PMID 14502648. S2CID 24956554.
  11. Agirre X, Jiménez-Velasco A, San José-Enériz E, Garate L, Bandrés E, Cordeu L, Aparicio O, Saez B, Navarro G, Vilas-Zornoza A, Pérez-Roger I, García-Foncillas J, Torres A, Heiniger A, Calasanz MJ, Fortes P, Román-Gómez J, Prósper F (Dec 2008). "Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth". Molecular Cancer Research. 6 (12): 1830–40. doi:10.1158/1541-7786.MCR-08-0167. PMID 19074828.

Further reading


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