Øyvind Ellingsen

Øyvind Ellingsen (born 1975) is a Norwegian Professor of Cellular Cardiology at the Norwegian University of Science and Technology (NTNU), a Consultant Physician at the Department of Cardiology, St. Olavs Hospital, Trondheim, Norway, and is currently Head of the Department of Circulation and Medical Imaging.[1] He received his MD and PhD at the University of Oslo, Norway, and had a postdoctoral fellowship at Harvard University, Massachusetts, U.S.A.

Øyvind Ellingsen
NationalityNorwegian
Known forExercise in Medicine
Scientific career
FieldsCardiology
InstitutionsDepartment of Circulation and Medical Imaging, NTNU

Dr. Ellingsen founded the Laboratory of Cellular Cardiology at NTNU in 1996. The focus of the lab is Exercise in Medicine. Its long-term goals are to understand the mechanisms of the beneficial effects of exercise in cardiovascular disease, to translate them into better programs for prevention and rehabilitation, and to identify new targets for medical therapy.

He currently participates in the HUNT-3 survey of physical activity, aerobic capacity, and endothelial function in Nord-Trøndelag County, Norway, is the Principal Investigator and Steering Committee Chairperson of the SMARTEX-HF multicenter trial[2] and is a collaborating partner of Cardiac Exercise Research Group (CERG).[3] He has been involved in scientific research on biomedical effects of meditation since 2006.

Education
  • 1996: Board approved specialist in internal (general) medicine
  • 1989: Doctor Medicinae (PhD, doctoral degree in medicine), University of Oslo, Norway. Thesis: "Myocardial potassium balance during adrenergic stimulation"
  • 1980: Candidatus Medicinae (MD, graduate degree in medicine), University of Oslo, Norway
  • 1971–1973: Technical Physics, University of Trondheim, Norway

Work experience
  • 2007– Head, Department of Circulation and Medical Imaging, NTNU
  • 2006–2007 Deputy Head, Department of Circulation and Medical Imaging, NTNU
  • 2003–2004 Visiting Scholar, Institute of Molecular Medicine, UCSD, Kenneth R. Chien Lab
  • 1996– Consultant Physician, Department of Cardiology, St. Olavs Hospital
  • 1995– Professor of Cellular Cardiology, Faculty of Medicine, NTNU
  • 1992–1994 Fellowship in Internal Medicine, Bærum Hospital, Sandvika, Norway
  • 1990–1992 International Fogarty Fellowship, Harvard University
  • 1988–1990 Fellowship in Internal Medicine, Ullevål Hospital, Oslo
  • 1983–1988 Research Fellowship, Dept. of Experimental Medical Research, University of Oslo
  • 1982–1983 Military Service, Lieutenant, Joint Military Health Services, Oslo, Norway
  • 1980–1982 Medical Internships, Bærum Hospital, Sandvika, Norway

Award

2005: The Ole Storstein’s Award for Excellent Cardiovascular Research in Norway

Membership

2008– The Royal Norwegian Society of Sciences and Letters [4]

Research abroad

2003–2004: Visiting Scholar, Institute of Molecular Medicine, UCSD, Kenneth R. Chien Lab 1990–1992: Postdoc, International Fogarty Fellowship in Professor Thomas W. Smith Lab, Brigham and Women's Hospital, Cardiovascular Division, Harvard University

Collaboration
International
  • 2006– Associate Professor Jim Lagopoulos, University of Sydney
  • 2004– Professor Reneé Ventura-Clapier, INSERM, Paris
  • 2004– Professor Gianluigi Condorelli, Parco Scientifico San Rafaele, Roma
  • 2002– Professor Steven L. Britton, Medical College of Ohio
  • 2001– Professor Volker Adams, University of Leipzig
  • 1997– Professor Godfrey L. Smith, University of Glasgow
National
  • 2006– Professor Svend Davanger, University of Oslo
  • 2006– Professor Are Holen, NTNU
  • 2006– Professor Geir Christensen, University of Oslo
  • 2001– Professor Ole M. Sejersted, University of Oslo
  • 2001– Professor Ulrik Wisløff, NTNU

Publications 2006–2011
  1. Sjåland C, Lunde PK, Swift F, Munkvik M, Ericsson M, Lunde M, Boye S, Christensen G, Ellingsen Ø, Sejersted OM, Andersson KB. Slowed relaxation and preserved maximal force in soleus muscles of mice with targeted disruption of the Serca-2 gene in skeletal muscle. J Physiol 2011 Sep 26 [Epub ahead of print]
  2. Koch LG, Kemi OJ, Qi N, Leng SX, Bijma P, Gilligan LJ, Wilkinson JE, Wisløff H, Høydal MA, Rolim N, Abadir PM, Grevenhof IV, Smith GL, Burant CF, Ellingsen Ø, Britton SL, Wisløff U. Intrinsic aerobic capacity sets a divide for aging and longevity. Circ Res 2011 Sep 15 [Epub ahead of print]
  3. Nesvold A, Fagerland MW, Davanger S, Ellingsen Ø, Solberg EE, Sevre K, Atar D. Increased heart rate variability during nondirective meditation. Eur J Cardiovasc Prev Rehabil 2011 Jun 21. [Epub ahead of print]
  4. Kemi OJ, Macquaide N, Høydal MA, Ellingsen Ø, Smith GL, Wisløff U. Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction in heart failure rats. J Cell Physiol 2011Apr 4. [Epub ahead of print]
  5. Støylen A, Conraads V, Halle M, Linke A, Prescott E, Ellingsen Ø. Controlled study of myocardial recovery after interval training in heart failure: SMARTEX-HF – rationale and design. Eur J Cardiovasc Prev Rehabil 2011 Mar 21. [Epub ahead of print]
  6. Kemi OJ, Høydal MA, Macquaide N, Haram PM, Koch LG, Britton SL, Ellingsen Ø, Smith GL, Wisløff U. The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts. J Cell Physiol 2011, 226: 2235–2243.
  7. Aspenes ST, Nilsen TI, Skaug EA, Bertheussen GF, Ellingsen Ø, Vatten L, Wisløff U. Peak oxygen uptake and cardiovascular risk factors in 4,631 healthy women and men. Med Sci Sports Exerc 2011, 43: 1465–1473.
  8. Ellingsen Ø. Energy at Heart: matching demand with production. Cardiovasc Res 2011, 90: 7–8.
  9. Davanger S, Ellingsen Ø, Holen A, Hugdal K. Meditation-specific prefrontal cortical activation during Acem meditation: an fMRI study. Percept Mot Skills 2010, 111: 291–306.
  10. Amundsen BH, Ericsson M, Seland JG, Pavlin T, Ellingsen Ø, Brekken C. A comparison of retrospectively self-gated magnetic resonance imaging and high-frequency echocardiography for characterization of left ventricular function in mice. Lab Anim 2011, 45: 31–37.
  11. Ericsson M, Sjåland C, Andersson KB, Sjaastad I, Christensen G, Sejersted OM, Ellingsen Ø. Exercise training before cardiac-specific Serca2 disruption attenuates the decline in cardiac function in mice. J Appl Physiol 2010, 109: 1749–1745.
  12. Ericsson M, Andersson KB, Amundsen BH, Torp SH, Sjaastad I, Christensen G, Sejersted OM, Ellingsen Ø. High-intensity exercise training in mice with cardiomyocyte-specific disruption of Serca-2. J Appl Physiol 2010, 108: 1311–1320.
  13. Lagopoulos J, Xu J, Rasmussen I, Vik A, Malhi GS, Eliassen CF, Arntsen IE, Saether JG, Hollup S, Holen A, Davanger S, Ellingsen Ø. Increased theta and alpha EEG activity during nondirective meditation. J Altern Complement Med 2009, 15: 1187–1192.
  14. Beisvag V, Kemi OJ, Arbo I, Loennechen LP, Wisløff U, Langaas M, Sandvik AK, Ellingsen Ø. Pathological and physiological hypertrophies are regulated by distinct gene programs. Eur J Cardiovasc Prev Rehabil 2009, 16: 690–607.
  15. Wisløff U, Ellingsen Ø, Kemi OJ. High-intensity interval training to maximize cardiac benefits of exercise training? Exerc Sport Sci Rev 2009, 37: 139–146.
  16. Bye A, Høydahl MA, Catalucci D, Langaas M, Kemi OJ, Beisvåg V, Koch LG, Britton SL, Ellingsen Ø, Wisløff U. Gene expression profiling of skeletal muscle in exercise-trained and sedentary rats with inborn high and low VO2max. Physiol Genomics 2008, 35: 213–221.
  17. Bye A, Sørhaug S, Ceci M, Høydal MA, Stølen T, Heinrich G, Tjønna AE, Najjar SM, Nilsen OG, Catalucci D, Grimaldi S, Contu R, Steinshamn S, Condorelli G, Smith GL, Ellingsen Ø, Waldum HL, Wisløff U. Carbon monoxide levels experienced by heavy smokers impair aerobic capacity and cardiac contractility and induce pathological hypertrophy. Inhal Toxicol 2008, 20: 635–646.
  18. Bye A, Langaas M, Høydal MA, Kemi OJ, Heinrich G, Koch LG, Britton SL, Najjar SM, Ellingsen Ø, Wisløff U. Aerobic capacity-dependent differences in cardiac gene expression. Physiol Genomics 2008, 33:100–109.
  19. Kemi OJ, Ellingsen Ø, Smith GL, Wisløff U. Exercise-induced changes in calcium handling in left ventricular cardiomyocytes. Front Biosci 2008, 13: 356–368. Review.
  20. Catalucci D, Latronico MV, Ellingsen Ø, Condorelli G. Physiological myocardial hypertrophy: how and why? Front Biosci 2008, 13: 312–324. Review.
  21. Kemi OJ, Ceci M, Wisløff U, Grimaldi S, Gallo P, Smith GL, Condorelli G, Ellingsen Ø. Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. J Cell Physiol 2008, 214: 316–321.
  22. Høydal MA, Wisløff U, Kemi OJ, Ellingsen Ø. Running speed and maximal oxygen uptake in rats and mice: Practical implications for exercise training. Eur J Cardiovasc Prev Rehabil 2007, 14: 753–760.
  23. Kemi OJ, Ellingsen Ø, Ceci M, Grimaldi S, Smith GL, Condorelli G, Wisløff U. Aerobic interval training enhances cardiomyocyte contractility and Ca(2+) cycling by phosphorylation of CaMKII and Thr-17 of phospholamban. J Mol Cell Cardiol 2007, 43: 354–361.
  24. Kemi OJ, Høydal MA, Haram PM, Garnier A, Fortin D, Ventura-Clapier R, Ellingsen Ø. Exercise training restores aerobic capacity and energy transfer systems in heart failure treated with losartan. Cardiovasc Res 2007, 76: 91–99.
  25. Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, Tjønna AE, Helgerud J, Slørdahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen Ø, Skjærpe T. Superior cardiovascular effect of aerobic interval-training versus moderate continuous training in heart failure patients: A randomized study. Circulation 2007, 115: 3086–3094.
  26. Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, Bang M-L, Segnalini P, Gu Y, Dalton ND, Elia L, Latronico MVG, Høydal M, Autore C, Russo MA, Dorn GW, Ellingsen Ø, Ruiz-Lozano P, Peterson KL, Croce CM, Peschle C, Condorelli G. MicroRNA-133 controls cardiac hypertrophy. Nat Med 2007, 613–618.
  27. Høydal MA, Wisløff U, Kemi OJ, Britton SL, Koch LG, Smith GL, Ellingsen Ø. Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. Eur J Cardiovasc Prev Rehabil 2007, 14: 319–325.
  28. Kemi OJ, Arbo I, Hoydal MA, Loennechen JP, Wisloff U, Smith GL, Ellingsen Ø. Reduced pH and contractility in failing rat cardiomyocytes. Acta Physiol 2006, 88:185–193.
  29. Haram PM, Adams V, Kemi OJ, Brubakk AO, Hambrecht R, Ellingsen Ø, Wisløff U. Time-course of endothelial adaptation following acute and regular exercise. Eur J Cardiovasc Prev Rehabil 2006, 13: 585–591.
  30. Beisvag V, Lehre PK, Midelfart H, Aass H, Geiran O, Sandvik AK, Laegreid A, Komorowski J, Ellingsen Ø. Aetiology-specific patterns in end-stage heart failure patients identified by functional annotation and classification of microarray data. Eur J Heart Fail 2006, 8: 381–389.
  31. Kemi OJ, Ellingsen Ø. Trans-sodium crocetinate does not affect oxygen uptake in rats during treadmill running. Scan J Clin Lab Invest 2005, 65: 577–584.
  32. Kemi OJ, Haram PM, Loennechen JP, Osnes J-B, Skomedal T, Wisløff U, Ellingsen Ø. Moderate vs. high exercise intensity: Differential effect on fitness, cardiomyocyte contractility, and endothelial function. Cardiovasc Res 2005, 67: 161–172.
  33. Wisløff U, Najjar SM, Ellingsen Ø, Haram PM, Swoap S, Al-Share Q, Fernström M, Rezaei K, Lee SJ, Koch LG, Britton SL. Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science 2005, 307: 418–420.
  34. Kemi OJ, Haram PM, Wisløff U, Ellingsen Ø. Aerobic fitness is associated with cardiomyocyte contractile capacity and endothelial function in exercise training and detraining. Circulation 2004, 109: 2897–2904.
  35. Wigen K, Holen A, Ellingsen Ø. Predicting academic success by group behaviour in PBL. Med Teach 2003, 25: 32–37.
  36. Beisvag V, Falck G, Loennechen JP, Qvigstad G, Jynge P, Skomedal T, Osnes J-B, Sandvik AK, Ellingsen Ø. Identification and regulation of the gastric H+/K+-ATPase in the rat heart. Acta Scand Physiol 2003, 179: 251–262.
  37. Kemi OJ, Loennechen JP, Wisløff U, Ellingsen Ø. Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy. J Appl Physiol 2002, 93: 1301–1309.
  38. Loennechen JP, Wisløff U, Falck G, Ellingsen Ø. Cardiomyocyte contractility and calcium handling partially recover after early deterioration during post-infarction failure in rat. Acta Physiol Scand 2002, 176: 17–26.
  39. Schiøtz Thorud HM, Wisløff U, Lunde PK, Christensen G, Ellingsen Ø, Sejersted OM. Surgical manipulation, but not moderate exercise, is associated with increased cytokine mRNA expression in the rat soleus muscle. Acta Physiol Scand 2002, 175: 219–226.
  40. Wisløff U, Loennechen JP, Currie S, Smith GL, Ellingsen Ø. Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction. Cardiovasc Res 2002, 54: 162–174.
  41. Loennechen JP, Wisløff U, Falck G, Ellingsen Ø. Effects of cariporide and losartan on hypertrophy, calcium transients, contractility, and gene expression in congestive heart failure. Circulation 2002, 105: 1380–1386.
  42. Loennechen JP, Nilsen OG, Arbo I, Aadahl P, Nilsen T, Waldum HL, Sandvik AK, Ellingsen Ø. Chronic exposure to carbon monoxide and nicotine: Endothelin ETA receptor antagonism attenuates carbon monoxide–induced myocardial hypertrophy in rat. Toxicol Appl Pharmacol 2002, 178: 8–14.
  43. Wisløff U, Helgerud J, Støylen A, Ellingsen Ø. Atrioventricular plane displacement in female endurance athletes. Med Sci Sports Exerc 2001, 33: 1503–1510.
  44. Wisløff U, Loennechen JP, Falck G, Beisvåg V, Currie S, Smith G, Ellingsen Ø. Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats. Cardiovasc Res 2001, 50: 495–508.
  45. Loennechen JP, Støylen A, Beisvåg V, Wisløff U, Ellingsen Ø. Regional expression of endothelin-1, ANP, IGF-1, and LV wall stress in the infarcted rat heart. Am J Physiol Heart Circ Physiol 2001, 280: H2902-H2910.
  46. Wisløff U, Helgerud J, Kemi OJ, Ellingsen Ø. Intensity-controlled treadmill running in rats: VO2max and cardiac hypertrophy. Am J Physiol Heart Circ Physiol 2001, 280: H1301-H1310.
  47. Medbø S, Beisvag V, Tølløfsrud PA, Ellingsen Ø, Wright MS. Attenuated endothelin-1 mRNA expression with endothelin-1 receptor blockade during hypoxaemia and reoxygenation in newborn piglets. Acta Paediatr 2000, 89: 698–702.
  48. Loennecehen JP, Beisvag V, Arbo I, Waldum HL, Sandvik AK, Knardahl S, Ellingsen Ø. Chronic carbon monoxide exposure in vivo induces myocardial endothelin-1 expression and hypertrophy in rat. Pharmacol Toxicol 1999, 85: 192–197.
  49. Davidoff AJ, Mäki TM, Ellingsen Ø, Marsh JD. Expression of calcium channels in adult cardiac myocytes is regulated by calcium. J Mol Cell Cardiol 1997, 29, 1791–1803.
  50. Ellingsen Ø, Holthe MR, Svindland A, Aksnes G, Sejersted OM, Ilebekk A. Na,K-pump concentration in hypertrophied human hearts. Eur Heart J 1994, 15: 1184–1190.
  51. Berger H-J, Prasad SK, Davidoff AJ, Pimental D, Ellingsen O, Marsh JD, Smith TW, Kelly RA. Continual electric field stimulation preserves contractile function of adult ventricular myocytes in primary culture. Am J Physiol 1994, 266: H341-H349.
  52. Ekeberg Ø, Ellingsen Ø, Jacobsen D. Mortality and causes of death in a 10-year follow-up of patients treated for self-poisonings in Oslo. Suicide Life Threat Behav 1994, 24: 398–405.
  53. Ellingsen Ø, Davidoff AJ, Prasad SK, Berger HJ, Springhorn JP, Marsh JD, Kelly RA, Smith TW. Adult rat ventricular myocytes cultured in defined medium: Phenotype and electromechanical function. Am J Physiol 1993, 265: H747-H754.
  54. Nishida M, Carley WW, Gerritsen ME, Ellingsen Ø, Kelly RA, Smith TW. Isolation and characterization of human and rat cardiac microvascular endothelial cells. Am J Physiol 1993, 264, H639-H652.
  55. Springhorn JP, Ellingsen Ø, Berger HJ, Kelly RA, Smith TW. Transcriptional regulation in cardiac muscle: Coordinate expression of Id with a neonatal phenotype during development and following a hypertrophic stimulus in adult rat ventricular myocytes in vitro. J Biol Chem 1992, 267: 14360–14365.
  56. Ellingsen Ø, Aksnes G, Ilebekk A. Calcium-induced net potassium uptake of pig hearts in vivo. Acta Physiol Scand 1992, 145: 99–104.
  57. Ekeberg Ø, Ellingsen Ø, Jacobsen D. Suicide and other causes of death in a five-year follow-up of patients treated for self-poisoning in Oslo. Acta Psychiatr Scand 1991, 83: 432–437.
  58. Ellingsen Ø, Sejersted OM, Vengen ØA, Ilebekk A. Frequency dependent myocardial potassium fluxes during beta-adrenergic stimulation of intact pig hearts. Cardiovasc Res 1991, 25: 364–370.
  59. Helgesen KG, Ellingsen Ø, Ilebekk A. Inotropic effect of meperidine: influence of receptor and ion channel blockers in the rat atrium. Anesth Analg 1990, 70: 499–506.
  60. Aksnes G, Ellingsen Ø, Rutlen DL, Ilebekk A. Effects of hemo¬dynamic variables on myocardial K+ balance during and after shortlasting ischemia. J Mol Cell Cardiol 1989, 21: 1273–1284.
  61. Aksnes G, Ellingsen Ø, Rutlen DL, Ilebekk A. Myocardial K+ repletion and rise in contractility after brief ischemic periods in the pig. J Mol Cell Cardiol 1989, 21: 681–690.
  62. Videm V, Fosse E, Mollnes TE, Ellingsen Ø, Pedersen T, Karlsen H. Different oxygenators for cardiopulmonary bypass lead to varying degrees of human complement activation in vitro. J Thor Cardio¬vasc Surg 1989, 97: 764–770.
  63. Vengen ØA, Ellingsen Ø, Ilebekk A. Factors reducing left and right ventricular output during simultaneous atrioventricular activation in the pig heart. Acta Physiol Scand 1989, 135: 477–486.
  64. Ellingsen Ø, Sejersted OM, Vengen ØA, Ilebekk A. In vivo quanti¬fication of myocardial Na,K-pump rate during beta-adrener¬gic stimulation of intact pig hearts. Acta Physiol Scand 1989, 135: 493–503.
  65. Ellingsen Ø. Myocardial potassium balance during adrenergic stimulation. J Oslo City Hosp 1989, 39: 39–51.
  66. Vengen ØA, Ellingsen Ø, Lande K, Ilebekk A. Significance of right atrial function during right sided inotropic stimulation of pig hearts in situ. Car¬diovasc Res 1988, 22: 875–880.
  67. Vengen ØA, Ellingsen Ø, Ilebekk A. Forward diastolic flow in pulmonary artery induced by right atrial contraction of in situ pig hearts. Am J Physiol 1988, 255: H228-H235.
  68. Ellingsen Ø, Vengen ØA, Sejersted OM, Ilebekk A. Temporal relationship of contractility and myocardial potassium balance following beta-adrenergic stimulation of the in situ pig heart. Acta Physiol Scand 1988, 132: 241–250.
  69. Ellingsen Ø, Vengen ØA, Kjeldsen SE, Eide I, Ilebekk A. Myocardial potassium uptake and catecholamine release during cardiac sympathetic nerve stimulation. Cardiovasc Res 1987, 21: 892–901.
  70. Videm V, Pillgram Larsen J, Ellingsen Ø, Andersen G, Øvrum E. Spontaneous pneumothorax in chronic obstructive pulmonary disease: Complications, treatment and recurrences. Eur J Respir Dis 1987, 71: 365–371.
  71. Ellingsen Ø, Vengen ØA, Ilebekk A. Myocardial potassium uptake during alpha- and beta-adrenoceptor stimulation. Am J Physiol 1987, 253: H799-H810.
  72. Videm V, Pillgram Larsen J, Andersen G, Øvrum E, Ellingsen Ø. Spontan pneumotoraks: Symptomer med og uten kronisk obstruktiv sykdom (Spontaneous pneumothorax: Symptoms with and without chronic obstructive pulmonary disease). Tidsskr Nor Lægeforen 1987, 107: 2123–2124.
  73. Videm V, Pillgram Larsen J, Fjeld NB, Ellingsen Ø. Spontan pneumotoraks: Drenbehandling (Spontaneous pneumothorax: Drainage Therapy). Tidsskr Nor Lægeforen 1987, 107: 2121–2122.
  74. Vengen ØA, Lande K, Ellingsen Ø, Ilebekk A. Cardiac adjust¬ments to left side inotropic stimulation of in situ pig hearts. Am J Physiol 1987, 252: H1164-H1174.
  75. Ellingsen Ø, Sejersted OM, Leraand S, Ilebekk A. Catechol¬amine induced myocardial potassium uptake mediated by beta-1adre¬noceptors and adenylate cyclase activation in the pig. Circ Res 1987, 60: 540–550.
  76. Ellingsen Ø, Kjekshus J. Prazosin ved anstrengelsesutløst angina pectoris (Prazosin in exercise induced angina pectoris). Tidsskr Nor Lægeforen 1984, 104: 657 660.

References
  1. The Department of Circulation and Medical Imaging (http://www.ntnu.edu/isb/contact)
  2. The SMARTEX Heart Failure Study (http://clinicaltrials.gov/ct2/show/NCT00917046)
  3. CERG (http://www.ntnu.edu/cerg)
  4. The Royal Norwegian Society of Sciences and Letters http://www.dknvs.no/english/
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