23S rRNA pseudouridine1911/1915/1917 synthase

23S rRNA pseudouridine1911/1915/1917 synthase (EC 5.4.99.23, RluD, pseudouridine synthase RluD) is an enzyme with systematic name 23S rRNA-uridine1911/1915/1917 uracil mutase.[1][2][3][4] This enzyme catalyses the following chemical reaction

23S rRNA uridine1911/uridine1915/uridine1917 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917
23S rRNA pseudouridine1911/1915/1917 synthase
Identifiers
EC number5.4.99.23
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

These nucleotides are located in the functionally important helix-loop 69 of 23S rRNA.

References
  1. Leppik M, Peil L, Kipper K, Liiv A, Remme J (November 2007). "Substrate specificity of the pseudouridine synthase RluD in Escherichia coli". The FEBS Journal. 274 (21): 5759–66. doi:10.1111/j.1742-4658.2007.06101.x. PMID 17937767.
  2. Ejby M, Sørensen MA, Pedersen S (December 2007). "Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination". Proceedings of the National Academy of Sciences of the United States of America. 104 (49): 19410–5. doi:10.1073/pnas.0706558104. PMC 2148303. PMID 18032607.
  3. Sivaraman J, Iannuzzi P, Cygler M, Matte A (January 2004). "Crystal structure of the RluD pseudouridine synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli". Journal of Molecular Biology. 335 (1): 87–101. doi:10.1016/j.jmb.2003.10.003. PMID 14659742.
  4. Wrzesinski J, Bakin A, Ofengand J, Lane BG (July 2000). "Isolation and properties of Escherichia coli 23S-RNA pseudouridine 1911, 1915, 1917 synthase (RluD)". IUBMB Life. 50 (1): 33–7. doi:10.1080/15216540050176566. PMID 11087118.


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