23S rRNA pseudouridine955/2504/2580 synthase
23S rRNA pseudouridine955/2504/2580 synthase (EC 5.4.99.24, RluC, pseudouridine synthase RluC) is an enzyme with systematic name 23S rRNA-uridine955/2504/2580 uracil mutase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 23S rRNA uridine955/uridine2504/uridine2580 23S rRNA pseudouridine955/pseudouridine2504/pseudouridine2580
| 23S rRNA pseudouridine955/2504/2580 synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.4.99.24 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme converts uridines at position 955, 2504 and 2580 of 23S rRNA to pseudouridines.
References
- Jiang M, Sullivan SM, Walker AK, Strahler JR, Andrews PC, Maddock JR (May 2007). "Identification of novel Escherichia coli ribosome-associated proteins using isobaric tags and multidimensional protein identification techniques". Journal of Bacteriology. 189 (9): 3434–44. doi:10.1128/jb.00090-07. PMC 1855874. PMID 17337586.
- Conrad J, Sun D, Englund N, Ofengand J (July 1998). "The rluC gene of Escherichia coli codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955, 2504, and 2580 in 23 S ribosomal RNA". The Journal of Biological Chemistry. 273 (29): 18562–6. doi:10.1074/jbc.273.29.18562. PMID 9660827.
- Corollo D, Blair-Johnson M, Conrad J, Fiedler T, Sun D, Wang L, Ofengand J, Fenna R (January 1999). "Crystallization and characterization of a fragment of pseudouridine synthase RluC from Escherichia coli" (PDF). Acta Crystallographica Section D. 55 (Pt 1): 302–4. doi:10.1107/s090744499801021x. PMID 10089432.
- Toh SM, Mankin AS (July 2008). "An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors". Journal of Molecular Biology. 380 (4): 593–7. doi:10.1016/j.jmb.2008.05.027. PMC 5367387. PMID 18554609.
External links
- 23S+rRNA+pseudouridine955/2504/2580+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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