34βE12

34βE12, often written as 34betaE12 and also known as CK34βE12 and keratin 903 (CK903), is an antibody specific for high molecular weight cytokeratins 1, 5, 10 and 14.[1][2]

It is sometimes, less precisely, referred to as high-molecular weight keratin (HMWK) and high-molecular weight cytokeratin (HMWCK).

Utility

It is used to stain basal cells in prostatic glands; loss of basal cells is seen in prostate adenocarcinoma (the most common form of prostate cancer).

It can be used to differentiate in situ cancers of the breast; lobular carcinoma in situ (LCIS) exhibits perinuclear staining with 34βE12. Ductal carcinoma in situ (DCIS) does not stain for 34βE12.[2]

See also

References
  1. Aishima S, Asayama Y, Taguchi K, et al. (November 2002). "The utility of keratin 903 as a new prognostic marker in mass-forming-type intrahepatic cholangiocarcinoma". Mod. Pathol. 15 (11): 1181–90. doi:10.1097/01.MP.0000032537.82380.69. PMID 12429797. S2CID 13065115.
  2. Yeh IT, Mies C (March 2008). "Application of immunohistochemistry to breast lesions". Arch. Pathol. Lab. Med. 132 (3): 349–358. doi:10.1043/1543-2165(2008)132[349:AOITBL]2.0.CO;2 (inactive 2021-01-10). PMID 18318578.CS1 maint: DOI inactive as of January 2021 (link)
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