4-hydroxyphenylacetaldehyde dehydrogenase
In enzymology, a 4-hydroxyphenylacetaldehyde dehydrogenase (EC 1.2.1.53) is an enzyme that catalyzes the chemical reaction
- 4-hydroxyphenylacetaldehyde + NAD+ + H2O 4-hydroxyphenylacetate + NADH + 2 H+
| 4-hydroxyphenylacetaldehyde dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.2.1.53 | ||||||||
| CAS number | 109456-56-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are 4-hydroxyphenylacetaldehyde, NAD+, and H2O, whereas its 3 products are 4-hydroxyphenylacetate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase. This enzyme is also called 4-HPAL dehydrogenase. This enzyme participates in tyrosine metabolism.
References
- Cuskey SM, Peccoraro V, Olsen RH (1987). "Initial catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO: pathway description, mapping of mutations, and cloning of essential genes". J. Bacteriol. 169 (6): 2398–404. PMC 212074. PMID 3034855.
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