7-cyano-7-deazaguanine synthase
7-cyano-7-deazaguanine synthase (EC 6.3.4.20, preQ0 synthase, 7-cyano-7-carbaguanine synthase, queC (gene)) is an enzyme with systematic name 7-carboxy-7-carbaguanine:ammonia ligase (ADP-forming).[1][2] This enzyme catalyses the following chemical reaction
- 7-carboxy-7-carbaguanine + NH3 + ATP 7-cyano-7-carbaguanine + ADP + phosphate + H2O
| 7-cyano-7-deazaguanine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 6.3.4.20 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme binds Zn2+.
References
- McCarty RM, Somogyi A, Lin G, Jacobsen NE, Bandarian V (May 2009). "The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps". Biochemistry. 48 (18): 3847–52. doi:10.1021/bi900400e. PMC 2693876. PMID 19354300.
- Cicmil N, Huang RH (August 2008). "Crystal structure of QueC from Bacillus subtilis: an enzyme involved in preQ1 biosynthesis". Proteins. 72 (3): 1084–8. doi:10.1002/prot.22098. PMID 18491386.
External links
- 7-cyano-7-deazaguanine+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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