ABI2

Abl interactor 2 also known as Abelson interactor 2 (Abi-2) is a protein that in humans is encoded by the ABI2 gene.[5][6][7]

ABI2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesABI2, ABI-2, ABI2B, AIP-1, AblBP3, SSH3BP2, argBP1, argBPIA, argBPIB, abl-interactor 2, abl interactor 2, AIP1
External IDsOMIM: 606442 MGI: 106913 HomoloGene: 4209 GeneCards: ABI2
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q33.2Start203,328,239 bp[1]
End203,447,728 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10152

329165

Ensembl

ENSG00000138443

ENSMUSG00000026782

UniProt

Q9NYB9

P62484

RefSeq (mRNA)

NM_001282925
NM_001282926
NM_001282927
NM_001282932
NM_005759

NM_001198570
NM_001198571
NM_198127

RefSeq (protein)

NP_001185499
NP_001185500
NP_937760

Location (UCSC)Chr 2: 203.33 – 203.45 MbChr 1: 60.41 – 60.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

ABI2 has been shown to interact with ABL1,[5][8] ADAM19,[9] and TRIM32.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000138443 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026782 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dai Z, Pendergast AM (December 1995). "Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity". Genes Dev. 9 (21): 2569–82. doi:10.1101/gad.9.21.2569. PMID 7590236.
  6. Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (September 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
  7. "Entrez Gene: ABI2 abl interactor 2".
  8. Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
  9. Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (September 2002). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424. S2CID 22611084.
  10. Kano S, Miyajima N, Fukuda S, Hatakeyama S (July 2008). "Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2". Cancer Res. 68 (14): 5572–80. doi:10.1158/0008-5472.CAN-07-6231. PMID 18632609.

Further reading


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