ACTL6B

ACTL6B
Identifiers
Aliases	ACTL6B, ACTL6, BAF53B, arpNalpha, actin like 6B, EIEE76, IDDSSAD
External IDs	OMIM: 612458 MGI: 1933548 HomoloGene: 81844 GeneCards: ACTL6B
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	100,656,448 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	137,569,582 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• structural constituent of cytoskeleton; • GO:0001105 transcription coactivator activity; • chromatin binding;
Cellular component	• cell nucleus; • nucleolus; • nBAF complex; • SWI/SNF complex; • NuA4 histone acetyltransferase complex;
Biological process	• nervous system development; • regulation of transcription, DNA-templated; • spinal cord development; • regulation of transcription from RNA polymerase II promoter; • transcription, DNA-templated; • chromatin remodeling; • cytoskeleton organization; • chromatin organization; • positive regulation of nucleic acid-templated transcription; • ATP-dependent chromatin remodeling; • histone H4 acetylation;
	Sources:Amigo / QuickGO
Orthologs
	51412
	83766
	ENSG00000077080
	ENSMUSG00000029712
	O94805
	Q99MR0
	NM_016188
	NM_031404
	NP_057272
	NP_113581
	Wikidata
View/Edit Human	View/Edit Mouse

Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.[5][6]

Function

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.[6]

Interactions

ACTL6B has been shown to interact with CTBP1.[7]

References

GRCh38: Ensembl release 89: ENSG00000077080 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029712 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (December 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
"Entrez Gene: ACTL6B actin-like 6B".
Oma Y, Nishimori K, Harata M (February 2003). "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP". Biochem. Biophys. Res. Commun. 301 (2): 521–528. doi:10.1016/S0006-291X(02)03073-5. PMID 12565893.

External links

Human ACTL6B genome location and ACTL6B gene details page in the UCSC Genome Browser.

Schafer DA, Schroer TA (2000). "Actin-related proteins". Annu. Rev. Cell Dev. Biol. 15: 341–363. doi:10.1146/annurev.cellbio.15.1.341. PMID 10611965.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Harata M, Mochizuki R, Mizuno S (1999). "Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues". Biosci. Biotechnol. Biochem. 63 (5): 917–923. doi:10.1271/bbb.63.917. PMID 10380635.
Olave I, Wang W, Xue Y, Kuo A, Crabtree GR (2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex". Genes Dev. 16 (19): 2509–2517. doi:10.1101/gad.992102. PMC 187451. PMID 12368262.
Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M (2003). "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex". Biochem. Biophys. Res. Commun. 299 (2): 328–334. doi:10.1016/S0006-291X(02)02637-2. PMID 12437990.
Oma Y, Nishimori K, Harata M (2003). "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP". Biochem. Biophys. Res. Commun. 301 (2): 521–528. doi:10.1016/S0006-291X(02)03073-5. PMID 12565893.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077080 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029712 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9799793-5] Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (December 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.

[entrez-6] "Entrez Gene: ACTL6B actin-like 6B".

[pmid12565893-7] Oma Y, Nishimori K, Harata M (February 2003). "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP". Biochem. Biophys. Res. Commun. 301 (2): 521–528. doi:10.1016/S0006-291X(02)03073-5. PMID 12565893.

ACTL6B

Function

Interactions

References

External links

Further reading