ADAM20

ADAM20
Identifiers
Aliases	ADAM20, ADAM metallopeptidase domain 20
External IDs	OMIM: 603712 MGI: 3045694 HomoloGene: 128364 GeneCards: ADAM20
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	70,535,015 bp[1]
Gene ontology
Molecular function	• peptidase activity; • metalloendopeptidase activity; • hydrolase activity; • metallopeptidase activity; • metal ion binding;
Cellular component	• integral component of membrane; • cell membrane; • membrane;
Biological process	• proteolysis; • single fertilization; • binding of sperm to zona pellucida;
	Sources:Amigo / QuickGO
Orthologs
	8748
	546055
	ENSG00000134007
	ENSMUSG00000054033
	O43506
	Q7M762
	NM_003814
	NM_001025380
	NP_003805
	NP_001020551
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 20 is an enzyme that in humans is encoded by the ADAM20 gene. It is a membrane disintegrin-metalloprotease that belongs to the ADAM family. It is exclusively expressed in Testes and is similar to sperm cell-specific fertilins -alpha and -beta.

Its cDNA was mapped, and was found to be tightly linked to marker SHGC-36001 on chromosome 14q24.1. ADAM 20 may be the functional equivalent of fertilin-alpha in humans.[4]

References

GRCh38: Ensembl release 89: ENSG00000134007 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hooft van Huijsduijnen R (January 1998). "ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha". Gene. 206 (2): 273–82. doi:10.1016/s0378-1119(97)00597-0. PMID 9469942.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134007 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Hooft van Huijsduijnen R (January 1998). "ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha". Gene. 206 (2): 273–82. doi:10.1016/s0378-1119(97)00597-0. PMID 9469942.