AFAP1

Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.[5][6][7][8]

AFAP1
Identifiers
AliasesAFAP1, AFAP, AFAP-110, AFAP110, actin filament associated protein 1
External IDsOMIM: 608252 MGI: 1917542 HomoloGene: 11009 GeneCards: AFAP1
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4p16.1Start7,758,714 bp[1]
End7,939,926 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

60312

70292

Ensembl

ENSG00000196526

ENSMUSG00000029094

UniProt

Q8N556

Q80YS6

RefSeq (mRNA)

NM_001134647
NM_021638
NM_198595
NM_001371090
NM_001371091

NM_027373

RefSeq (protein)

NP_001128119
NP_940997
NP_001358019
NP_001358020

NP_081649

Location (UCSC)Chr 4: 7.76 – 7.94 MbChr 5: 35.89 – 36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000196526 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029094 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC (Feb 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem. 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689. S2CID 38130241.
  6. Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC (Oct 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene. 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786.
  7. Baisden JM, Qian Y, Zot HM, Flynn DC (Oct 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene. 20 (44): 6435–47. doi:10.1038/sj.onc.1204784. PMID 11607843.
  8. "Entrez Gene: AFAP1 actin filament associated protein 1".

Further reading


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