AGTPBP1 (gene)
ATP/GTP binding protein 1 is gene that encodes the protein known as cytosolic carboxypeptidase 1 (CCP1), originally named NNA1. Mice with a naturally occurring mutation of the Agtpbp1 gene are known as pcd mice (Purkinje cell degeneration). [5]
Function
CCP1/NNA1 is a zinc carboxypeptidase that contains nuclear localization signals that was initially cloned from regenerating spinal cord neurons of the mouse. Although originally thought to contain an ATP/GTP-binding motif, this was not experimentally verified, and the potential domain is not conserved through evolution.
[supplied by OMIM, Jul 2002].
References
- GRCh38: Ensembl release 89: ENSG00000135049 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000021557 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: ATP/GTP binding protein 1". Retrieved 2018-06-13.
Further reading
- Thakar K, Karaca S, Port SA, Urlaub H, Kehlenbach RH (March 2013). "Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry". Mol. Cell. Proteomics. 12 (3): 664–78. doi:10.1074/mcp.M112.024877. PMC 3591659. PMID 23242554.
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