AGTPBP1 (gene)

ATP/GTP binding protein 1 is gene that encodes the protein known as cytosolic carboxypeptidase 1 (CCP1), originally named NNA1. Mice with a naturally occurring mutation of the Agtpbp1 gene are known as pcd mice (Purkinje cell degeneration). [5]

AGTPBP1
Identifiers
AliasesAGTPBP1, CCP1, NNA1, ATP/GTP binding protein 1, CONDCA
External IDsOMIM: 606830 MGI: 2159437 HomoloGene: 9067 GeneCards: AGTPBP1
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q21.33Start85,546,539 bp[1]
End85,742,029 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23287

67269

Ensembl

ENSG00000135049

ENSMUSG00000021557

UniProt

Q9UPW5

Q641K1

RefSeq (mRNA)

NM_001286715
NM_001286717
NM_015239
NM_001330701

RefSeq (protein)

NP_001273644
NP_001273646
NP_001317630
NP_056054
NP_056054.2

Location (UCSC)Chr 9: 85.55 – 85.74 MbChr 13: 59.45 – 59.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

CCP1/NNA1 is a zinc carboxypeptidase that contains nuclear localization signals that was initially cloned from regenerating spinal cord neurons of the mouse. Although originally thought to contain an ATP/GTP-binding motif, this was not experimentally verified, and the potential domain is not conserved through evolution.

[supplied by OMIM, Jul 2002].

References

  1. GRCh38: Ensembl release 89: ENSG00000135049 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021557 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ATP/GTP binding protein 1". Retrieved 2018-06-13.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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