AH-494

AH-494
Identifiers
	IUPAC name 3‐(1‐ethyl‐1H‐imidazol‐5‐yl)‐1H‐indole‐5‐carboxamide;
PubChem CID	138691364;
ChemSpider	68912051;
Chemical and physical data
Formula	C14H14N4O
Molar mass	254.293 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCn1cncc1-c1c[nH]c2ccc(cc12)C(N)=O;
	InChI InChI=1S/C14H14N4O/c1-2-18-8-16-7-13(18)11-6-17-12-4-3-9(14(15)19)5-10(11)12/h3-8,17H,2H2,1H3,(H2,15,19); Key:RXDHCCKYQJNUFV-UHFFFAOYSA-N;

AH-494 is a potent and selective, water soluble full agonist at the 5HT₇ serotonin receptor. It is a close derivative of the known chemical probe 5-Carboxamidotryptamine, as well as of the more lipophilic indole-imidazoles: AGH-107 and AGH-192. It has been shown to exhibit favorable ADMET profile in in vitro assays.[1]

References

Latacz G, Hogendorf AS, Hogendorf A, Lubelska A, Wierońska JM, Woźniak M, Cieślik P, Kieć-Kononowicz K, Handzlik J, Bojarski AJ (September 2018). "Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists". MedChemComm. 9 (11): 1882–1890. doi:10.1039/c8md00313k. PMC 6256855. PMID 30568756.

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[pmid30568756-1] Latacz G, Hogendorf AS, Hogendorf A, Lubelska A, Wierońska JM, Woźniak M, Cieślik P, Kieć-Kononowicz K, Handzlik J, Bojarski AJ (September 2018). "Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists". MedChemComm. 9 (11): 1882–1890. doi:10.1039/c8md00313k. PMC 6256855. PMID 30568756.

AH-494

See also

References