APIP

APAF1-interacting protein is a protein that in humans is encoded by the APIP gene.[5][6][7] It is an enzyme with Methylthioribulose 1-phosphate dehydratase activity[8][9] which is involved in the methionine salvage pathway.

APIP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPIP, APIP2, CGI29, MMRP19, hCGI-29, APAF1 interacting protein
External IDsOMIM: 612491 MGI: 1926788 HomoloGene: 6277 GeneCards: APIP
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p13Start34,853,094 bp[1]
End34,916,379 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51074

56369

Ensembl

ENSG00000149089

ENSMUSG00000010911

UniProt

Q96GX9

Q9WVQ5

RefSeq (mRNA)

NM_015957

NM_019735
NM_001355473
NM_001355474

RefSeq (protein)

NP_057041

NP_062709
NP_001342402
NP_001342403

Location (UCSC)Chr 11: 34.85 – 34.92 MbChr 2: 103.07 – 103.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

APIP deficiency is associated with cell death[10] and cancer.

Interactions

APIP has been shown to interact with APAF1.[6]

References
  1. GRCh38: Ensembl release 89: ENSG00000149089 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000010911 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  6. Cho DH, Hong YM, Lee HJ, Woo HN, Pyo JO, Mak TW, Jung YK (Sep 2004). "Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein". J Biol Chem. 279 (38): 39942–50. doi:10.1074/jbc.M405747200. PMID 15262985.
  7. "Entrez Gene: APIP APAF1 interacting protein".
  8. Mary C, Duek P, Salleron L, Tienz P, Bumann D, Bairoch A, Lane L (2012). Di Cunto F (ed.). "Functional Identification of APIP as Human mtnB, a Key Enzyme in the Methionine Salvage Pathway". PLOS ONE. 7 (12): e52877. doi:10.1371/journal.pone.0052877. PMC 3532061. PMID 23285211.
  9. Kang, W; Hong, S. H.; Lee, H. M.; Kim, N. Y.; Lim, Y. C.; Le Le, T. M.; Lim, B; Kim, H. C.; Kim, T. Y.; Ashida, H; Yokota, A; Hah, S. S.; Chun, K. H.; Jung, Y. K.; Yang, J. K. (2014). "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme". Proceedings of the National Academy of Sciences. 111 (1): E54-61. doi:10.1073/pnas.1308768111. PMC 3890807. PMID 24367089.
  10. Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI (2012). "Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death". Proceedings of the National Academy of Sciences. 109 (35): E2343–E2352. doi:10.1073/pnas.1206701109. PMC 3435171. PMID 22837397.

Further reading
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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