APLP1

Amyloid-like protein 1, also known as APLP1, is a protein that in humans is encoded by the APLP1 gene.[5][6] APLP1 along with APLP2 are important modulators of glucose and insulin homeostasis.[7]

APLP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPLP1, APLP, amyloid beta precursor like protein 1
External IDsOMIM: 104775 MGI: 88046 HomoloGene: 68447 GeneCards: APLP1
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.12Start35,867,899 bp[1]
End35,879,791 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

333

11803

Ensembl

ENSG00000105290

ENSMUSG00000006651

UniProt

P51693

Q03157

RefSeq (mRNA)

NM_005166
NM_001024807

NM_007467

RefSeq (protein)

NP_001019978
NP_005157

NP_031493

Location (UCSC)Chr 19: 35.87 – 35.88 MbChr 7: 30.43 – 30.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.[5]

APLP1 and APLP2 double knockout mice display hypoglycemia and hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000105290 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000006651 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: APLP1 amyloid beta (A4) precursor-like protein 1".
  6. Wasco W, Brook JD, Tanzi RE (January 1993). "The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19". Genomics. 15 (1): 237–9. doi:10.1006/geno.1993.1047. PMID 8432545.
  7. Needham BE, Wlodek ME, Ciccotosto GD, Fam BC, Masters CL, Proietto J, Andrikopoulos S, Cappai R (June 2008). "Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth". J. Pathol. 215 (2): 155–63. doi:10.1002/path.2343. PMID 18393365. S2CID 1064378.

Further reading

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