APPBP2

Amyloid protein-binding protein 2 is a protein that in humans is encoded by the APPBP2 gene.[4][5]

APPBP2
Identifiers
AliasesAPPBP2, APP-BP2, HS.84084, PAT1, amyloid beta precursor protein binding protein 2
External IDsOMIM: 605324 MGI: 1914134 HomoloGene: 31378 GeneCards: APPBP2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q23.2Start60,443,158 bp[1]
End60,526,242 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10513

66884

Ensembl

ENSG00000062725

ENSMUSG00000018481

UniProt

Q92624

Q9DAX9

RefSeq (mRNA)

NM_001282476
NM_006380

NM_025825

RefSeq (protein)

NP_001269405
NP_006371

NP_080101

Location (UCSC)Chr 17: 60.44 – 60.53 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene.[5]

Interactions

APPBP2 has been shown to interact with Amyloid precursor protein.[4]{

References

  1. GRCh38: Ensembl release 89: ENSG00000062725 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Zheng P, Eastman J, Vande Pol S, Pimplikar SW (Jan 1999). "PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein". Proc Natl Acad Sci U S A. 95 (25): 14745–50. doi:10.1073/pnas.95.25.14745. PMC 24520. PMID 9843960.
  5. "Entrez Gene: APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2".

Further reading


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