ARHGAP5

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.[5][6]

ARHGAP5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARHGAP5, GFI2, RhoGAP5, p190-B, p190BRhoGAP, Rho GTPase activating protein 5
External IDsOMIM: 602680 MGI: 1332637 HomoloGene: 907 GeneCards: ARHGAP5
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q12Start32,076,114 bp[1]
End32,159,728 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

394

11855

Ensembl

ENSG00000100852

ENSMUSG00000035133

UniProt

Q13017

P97393

RefSeq (mRNA)

NM_001030055
NM_001173

NM_009706

RefSeq (protein)

NP_001025226
NP_001164

NP_033836

Location (UCSC)Chr 14: 32.08 – 32.16 MbChr 12: 52.5 – 52.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family that may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

ARHGAP5 has been shown to interact with Rnd1,[7] Rnd2,[7] Rnd3[7] and RHOA.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000100852 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035133 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Burbelo PD, Miyamoto S, Utani A, Brill S, Yamada KM, Hall A, Yamada Y (1995). "p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking". J. Biol. Chem. 270 (52): 30919–26. doi:10.1074/jbc.270.52.30919. PMID 8537347.
  6. "Entrez Gene: ARHGAP5 Rho GTPase activating protein 5".
  7. Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. PMC 6918695. PMID 12842009.

Further reading


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