ARL4A

ADP-ribosylation factor-like protein 4A is a protein that in humans is encoded by the ARL4A gene.[5]

ARL4A
Identifiers
AliasesARL4A, ARL4, ADP ribosylation factor like GTPase 4A
External IDsOMIM: 604786 MGI: 99437 HomoloGene: 4194 GeneCards: ARL4A
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7p21.3Start12,686,856 bp[1]
End12,690,958 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10124

11861

Ensembl

ENSG00000122644

ENSMUSG00000047446

UniProt

P40617

P61213

RefSeq (mRNA)

NM_212460
NM_001037164
NM_001195396
NM_005738

NM_001039515
NM_007487

RefSeq (protein)

NP_001032241
NP_001182325
NP_005729
NP_997625

NP_001034604
NP_031513

Location (UCSC)Chr 7: 12.69 – 12.69 MbChr 12: 40.01 – 40.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene.[5]

Interactions

ARL4A has been shown to interact with Karyopherin alpha 2.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000122644 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000047446 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ARL4A ADP-ribosylation factor-like 4A".
  6. Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (December 2000). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". J. Biol. Chem. 275 (48): 37815–23. doi:10.1074/jbc.M002470200. PMID 10980193.

Further reading


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