ARMCX5

ARMCX5 is an armadillo repeat–containing protein that is encoded by the X-linked ARMCX5 gene. It is conserved only in Eutheria,[1] a specific group of placental mammals, but no further back in evolutionary time. ARMCX5 contains 3 ARM-like repeats, DUF364, and ARM-type fold.[2]

Features
Accession Number NC_0002.10
Aliases FLJ12969, FLJ13382, and RP4-769N13.3
Chromosomal location Xq22.1-q22.3
Gene size 4991 base pairs
mRNA size 2924 base pairs
Protein size 588 amino acids

[3]


Splice Variants

ARMCX5 has 6 splice variants.

Splice isoform/transcript variant mRNA sequence length Accession number
1 2924 NM_001168479.1
2 2695 NM_022838.3
3 2808 NM_001168478.1
4 2918 NM_001168480.1
5 2805 NM_001168485.1
6 2707 NM_001168482.1

[3]

ORTHOLOGS

ARMCX5 has ten orthologs.

Ortholog genus name Common name Accession number Sequence length Sequence identity Sequence similarity
Pongo abelli Orangatuan XP_002831961.1 547 97.1% 99%
Macaca mulata Rhesus monkey EHH30927.1 558 95.3% 97%
Macaca fascicularis Crab eating macaque EHH61076.1 558 95% 97%
Callithrix Jacchus Common marmoset XP_002763850.1 568 89.4% 93%
Equus caballus Horse NC009175.2 609 80% 85%
Canis lupus familiaris dog XP_538116.2 608 79% 85%
Sus scrofa Common pig XP_003135327.2 732 78% 85%
Oryctolagus cuniculus Common rabbit XP_00272091.1 547 76.8% 85%
Rattus norvegicus Common rat XP_001499348.2 567 61.1% 76%
Mus musculus Mouse NP_001009575.2 606 57% 71%

[4]

Paralogs

ARMCX5 has 8 paralogs listed by genecards: GPRASP2, ARMCX1, BHLHB9, ARMCX2, GPRASP1, ARMCX6, ARMCX10, and ARMCX3.[2]

Function

Proteins containing this ARMCX5 domain interact with numerous other proteins. Through these interactions, they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation f circadian rhythm and lysosomal sorting of G-protein coupled receptors.[2]

Because DUF364 contains a PLP-dependent transferase-like fold, the genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis.[5]

Expression

ARMCX5 is a highly ubiquitously expressed gene that has shown expression in many tissues.

Body Site Transcripts per million Gene EST/Total EST in pool
Brain 25 28/1092524
Bone marrow 82 4/48711
Mouth 60 4/66139
Vascular 58 3/51637
Spleen 56 3/53365
Mammary gland 52 8/151228
Esophagus 49 1/20152
Larynx 42 1/23489
Trachea 38 2/51769
Muscle 37 4/106323
Testes 33 11/327305

[6]

References
  1. "BLAT". UCSC Genome Bioinformatics.
  2. "ARMCX5". Gene cards.
  3. "NCBI- nucleotide".
  4. "NCBI BLAST".
  5. "NCBI-protein".
  6. "NCBI-EST profiles".
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