ASF1A

Histone chaperone ASF1A is a protein that in humans is encoded by the ASF1A gene.[5][6][7]

ASF1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesASF1A, CGI-98, CIA, HSPC146, anti-silencing function 1A histone chaperone
External IDsOMIM: 609189 MGI: 1913653 HomoloGene: 8528 GeneCards: ASF1A
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q22.31Start118,894,152 bp[1]
End118,909,171 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

25842

66403

Ensembl

ENSG00000111875

ENSMUSG00000019857

UniProt

Q9Y294

Q9CQE6

RefSeq (mRNA)

NM_014034

NM_025541

RefSeq (protein)

NP_054753

NP_079817

Location (UCSC)Chr 6: 118.89 – 118.91 MbChr 10: 53.6 – 53.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.[7]

Interactions

ASF1A has been shown to interact with TLK1,[8][9] TLK2,[8] CHAF1B[10] and CHAF1A.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000111875 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019857 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  6. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  7. "Entrez Gene: ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae)".
  8. Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068–73. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414. S2CID 8866062.
  9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  10. Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056. PMID 11897662.

Further reading

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