ATG4B

Cysteine protease ATG4B is an enzyme that in humans is encoded by the ATG4B gene.[5]

ATG4B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesATG4B, APG4B, AUTL1, autophagy related 4B cysteine peptidase
External IDsOMIM: 611338 MGI: 1913865 HomoloGene: 100868 GeneCards: ATG4B
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q37.3Start241,637,213 bp[1]
End241,673,857 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23192

66615

Ensembl

ENSG00000168397

ENSMUSG00000026280

UniProt

Q9Y4P1

Q8BGE6

RefSeq (mRNA)

NM_013325
NM_178326

NM_174874
NM_001368266

RefSeq (protein)

NP_037457
NP_847896

NP_777363
NP_001355195

Location (UCSC)Chr 2: 241.64 – 241.67 MbChr 1: 93.75 – 93.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5] One main function of Atg4 is to cleave the pre-protein of Atg8, leading to the non-lipidated soluble (-I) form which can be processed further by Atg3, Atg7, Atg5-12 into the lipidated form (-II) anchored to the autophagic membrane.

Interactions

ATG4B has been shown to interact with GABARAPL2.[6][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000168397 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026280 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae)".
  6. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  7. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

Further reading

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