Acridine carboxamide

Acridine carboxamide
Identifiers
	IUPAC name N-[2-(Dimethylamino)ethyl]-4-acridinecarboxamide;
CAS Number	89459-25-6;
PubChem CID	107805;
ChemSpider	96954;
UNII	0N3V8R4E13;
CompTox Dashboard (EPA)	DTXSID60237739 ;
Chemical and physical data
Formula	C8H19N3O
Molar mass	173.260 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCNC(=O)C1=CC=CC2=CC3=CC=CC=C3N=C21;
	InChI InChI=1S/C18H19N3O/c1-21(2)11-10-19-18(22)15-8-5-7-14-12-13-6-3-4-9-16(13)20-17(14)15/h3-9,12H,10-11H2,1-2H3,(H,19,22); Key:XBGNERSKEKDZDS-UHFFFAOYSA-N;

Acridine carboxamide is a chemotherapy agent that is being studied in the treatment of cancer. It belongs to the family of drugs called topoisomerase inhibitors.

While the agent was well tolerated in Phase II clinical trials, it did not show efficacy when tested against various types of cancers.[1][2][3][4]

References

Dittrich C, Dieras V, Kerbrat P, Punt C, Sorio R, Caponigro F, et al. (August 2003). "Phase II study of XR5000 (DACA), an inhibitor of topoisomerase I and II, administered as a 120-h infusion in patients with advanced ovarian cancer". Investigational New Drugs. 21 (3): 347–52. doi:10.1023/A:1025476813365. PMID 14578683. S2CID 19095200.
Caponigro F, Dittrich C, Sorensen JB, Schellens JH, Duffaud F, Paz Ares L, et al. (January 2002). "Phase II study of XR 5000, an inhibitor of topoisomerases I and II, in advanced colorectal cancer". European Journal of Cancer. 38 (1): 70–4. doi:10.1016/S0959-8049(01)00336-7. PMID 11750842.
Twelves C, Campone M, Coudert B, Van den Bent M, de Jonge M, Dittrich C, et al. (May 2002). "Phase II study of XR5000 (DACA) administered as a 120-h infusion in patients with recurrent glioblastoma multiforme". Annals of Oncology. 13 (5): 777–80. doi:10.1093/annonc/mdf121. PMID 12075748.
Dittrich C, Coudert B, Paz-Ares L, Caponigro F, Salzberg M, Gamucci T, et al. (February 2003). "Phase II study of XR 5000 (DACA), an inhibitor of topoisomerase I and II, administered as a 120-h infusion in patients with non-small cell lung cancer". European Journal of Cancer. 39 (3): 330–4. doi:10.1016/S0959-8049(02)00559-2. PMID 12565985.

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