Adrenodoxin-NADP+ reductase

Adrenodoxin-NADP+ reductase (EC 1.18.1.6, adrenodoxin reductase, nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, ADR, NADPH:adrenal ferredoxin oxidoreductase) is an enzyme with systematic name adrendoxin:NADP+ oxidoreductase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

2 reduced adrenodoxin + NADP+ 2 oxidized adrenodoxin + NADPH + H+
Adrenodoxin-NADP+ reductase
Identifiers
EC number1.18.1.6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Adrenodoxin-NADP+ reductase is a flavoprotein (FAD).

References
  1. Omura T, Sanders E, Estabrook RW, Cooper DY, Rosenthal O (1966). "Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase". Arch. Biochem. Biophys. 117 (3): 660–673. doi:10.1016/0003-9861(66)90108-1.
  2. Chu JW, Kimura T (March 1973). "Studies on adrenal steroid hydroxylases. Molecular and catalytic properties of adrenodoxin reductase (a flavoprotein)". The Journal of Biological Chemistry. 248 (6): 2089–94. PMID 4144106.
  3. Sugiyama T, Yamano T (March 1975). "Purification and crystallization of NADPH-adrenodoxin reductase from bovine adrenocortical mitochondria". FEBS Letters. 52 (1): 145–8. doi:10.1016/0014-5793(75)80658-2. PMID 235468.
  4. Hanukoglu I, Jefcoate CR (April 1980). "Mitochondrial cytochrome P-450scc. Mechanism of electron transport by adrenodoxin". The Journal of Biological Chemistry. 255 (7): 3057–61. PMID 6766943.
  5. Hanukoglu I, Hanukoglu Z (May 1986). "Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation". European Journal of Biochemistry. 157 (1): 27–31. doi:10.1111/j.1432-1033.1986.tb09633.x. PMID 3011431.
  6. Hanukoglu I, Gutfinger T (March 1989). "cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases". European Journal of Biochemistry. 180 (2): 479–84. doi:10.1111/j.1432-1033.1989.tb14671.x. PMID 2924777.
  7. Ziegler GA, Vonrhein C, Hanukoglu I, Schulz GE (June 1999). "The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis". Journal of Molecular Biology. 289 (4): 981–90. doi:10.1006/jmbi.1999.2807. PMID 10369776.
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