Albert Kurland

With Cholden and Savage, Kurland published his first peer reviewed research on psychedelics in 1955.[4] Entitled "Clinical reactions and tolerance to LSD in chronic schizophrenia," the study sought to ascertain reactions to LSD among “chronic, regressed, schizophrenic patients” so that results could be compared to earlier research that described reactions of LSD among other subjects. This information was preliminary to the study's second aim, which was to examine the clinical and therapeutic potential of LSD. The research team also sought to replicate research conducted by Abram Hoffer and Humphrey Osmond who had done earlier LSD research in Canada beginning in 1952.[5]

Kurland's work with Cholden and Savage predated their efforts in the subsequent Spring Grove experiment.

Unlike previous research on LSD, Kurland and his peers administered LSD intramuscularly, providing better control of dosing patients who often did not swallow oral doses completely. The team also took steps to allow patients to adjust to new research settings such that any reactions to LSD would be independent of reactions associated with environmental change.

Kurland and his colleagues found that reactions to LSD in the regressed schizophrenic subjects had at least three types: (1) covert reactions, in which no striking behavioral change was observed (e.g. patients became withdrawn), (2) intensified reactions, in which subjects presented increased agitation, anxiety or delusion and (3) reversed reactions, in which behaviors changed dramatically from what was typical (e.g. hostile patients became friendly).  This research also found that tolerance to LSD was not entirely psychological in nature because cross-tolerance with brom-lysergic acid was present while cross-tolerance with mescaline was negative. Finally, the team provided observations of how much time was required before larger doses of LSD were necessary to have the same impact as an initial dose.

Kurland's research at Spring Grove was not unique. According to Dyck's analysis, there were at least 100 articles on LSD by 1951, over 500 by the end of the 1950s, and ten years later there were more than 1000. However, Kurland and his team developed a research program that was the most ambitious and longstanding of its kind. According to one of Kurland's subsequent co-authors:

The body of research that emerged from these 23 years of study [at Spring Grove] remains the largest, most sustained and systematic research into therapeutic use of psychedelic drugs and psychotherapy yet attempted.[6]

Kurland's 1955 research on LSD paused until the 1960s when Sanford Unger arrived at Spring Grove. Unger was a psychologist from Hollywood Hospital in Vancouver, British Columbia. By 1963, Kurland was collaborating with Unger and Charles Savage in renewed research, examining the efficacy of LSD in treating alcoholics and subsequently cancer patients.[2]

Kurland's continued research on LSD in the 1960s and 1970s was complicated by the “moral panic” the general population had about the drug as well as by increased regulations for medical research. Additionally, LSD research posed methodological complications in observing the drug's effects on treatment and control groups. While the standard in medical research was a double-blind study, the effects of LSD were obvious to investigators. For these reasons, LSD research waned by the late 1970s. Today, however, research on the efficacy of psychedelics continues.

Kurland published with various colleagues nearly 50 studies on antipsychotics, beginning with his study of chlorpromazine (Thorazine) in 1955.[7] Chlorpromazine had been shown to have useful applications by French psychiatrists Jean Delay and Pierre Deniker, and then in Canada under research directed by Heinz Lehmann. Kurland's first chlorpromazine study (1955) was conducted concurrently with research underway by Joel Elkes, who was examining the substance in 1954 from Birmingham, England. Kurland's research on the effectiveness of antipsychotics addressed numerous diseases, including schizophrenia, addiction, psychosis and other acute psychiatric illnesses.

Kurland published 14 articles on antidepressant medications, including nialamide, aletamine, dilantin, amoxapine among others. His later research included studies that aided the development of buproprion.

Among his published research, Kurland analyzed a variety of other clinical treatments for depression, addiction, anxiety and other diseases. His investigations of haloanisone, pyridoxine, and perphenazine-benztropine mesylate, are examples of the broad range of compounds that Kurland studied while his focus on other antipsychotics and psychedelics continued. Even more publications evidence Kurland's examination of general topics in psychiatry not directly related to clinical treatments, but describe appropriate admission procedures for psychiatric patients or the role of patients' general practitioners.[7]

Kurland's attempts to observe the human condition were not limited to traditional research methodology common in medical science. While he typically utilized standard methodological protocols in his published work, he also considered phenomena that did not easily fit within the quantitative, positivist perspectives common in medical research. For example, as described by his former colleague Stanislav Grof, Kurland invited Joan Grant and Dennys Kelsey, European therapists who used hypnotic therapy to assist patients uncover past lives, to a symposium to inform research on the compound.