Aldehyde oxidase 1

Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene.[5][6]

AOX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAOX1, AO, AOH1, aldehyde oxidase 1
External IDsOMIM: 602841 MGI: 88035 HomoloGene: 68165 GeneCards: AOX1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q33.1Start200,586,014 bp[1]
End200,677,064 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

316

11761

Ensembl

ENSG00000138356

ENSMUSG00000063558

UniProt

Q06278

O54754

RefSeq (mRNA)

NM_001159

NM_009676

RefSeq (protein)

NP_001150

NP_033806

Location (UCSC)Chr 2: 200.59 – 200.68 MbChr 1: 58.03 – 58.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide.[5]

Clinical significance

Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000138356 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000063558 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: aldehyde oxidase 1".
  6. Berger R, Mezey E, Clancy KP, Harta G, Wright RM, Repine JE, Brown RH, Brownstein M, Patterson D (March 1995). "Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis". Somat. Cell Mol. Genet. 21 (2): 121–31. doi:10.1007/BF02255787. PMID 7570184. S2CID 24691533.

Further reading


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