Aleksandra Filipovska

Aleksandra Filipovska is a Senior Research Fellow at the University of Western Australia (School of Chemistry and Biochemistry), heading a research group at the Harry Perkins Institute of Medical Research.[1][2] Specializing in biochemistry and molecular biology, she has made contributions to the understanding of human mitochondrial genetics in health and disease.[3]

Education and training

After graduating with a Bachelor of Science (with Honors) in 1998, Filipovska received her Ph.D. at the University of Otago, New Zealand in 2002.[4] Between 2003-2005 she completed postdoctoral training as a New Zealand Foundation for Research, Science and Technology Fellow at the MRC Mitochondrial Biology Unit in Cambridge, the United Kingdom, before relocating to Australia in 2006 as a National Health and Medical Research Council of Australia (NHMRC) Howard Florey Fellow. From 2009-2014 she was an Australian Research Council (ARC) Future Fellow. She is currently supported by an NHMRC Senior Research Fellowship as well as project grants from the NHMRC and ARC.[5][6]

Research focus

Filipovska's research focuses on mitochondria, the 'powerhouses' that provide all human cells with energy. Dysfunction of mitochondria contributes to a variety of debilitating human diseases including neurodegenerative disorders, diabetes and cancer. During her graduate studies, Filipovska investigated how mutations in genes encoding for mitochondrial proteins can lead to disease, and developed new approaches to manipulate mitochondrial DNA replication and expression as potential therapies.[3][6] During her postdoctoral work, she explored the use of compounds targeting mitochondria as a means to reduce oxidative stress in cells during aging and disease.[6] Since establishing her research group at the Harry Perkins Institute of Medical Research, Filipovska has continued to focus on the molecular mechanisms by which changes in mitochondrial gene expression causes disease. Working with collaborators at the University of Western Australia, she recently identified a communication problem between a calcium channel in muscle cells and the protein dystrophin, which may underlie heart failure in muscular dystrophy patients.[7][8]

Awards and prizes

Filipovska has been awarded the:

References
  1. Harry Perkins Institute of Medical Research. "Professor Aleksandra Filipovska PhD". Retrieved 14 August 2014.
  2. "Staff Profile: Prof Aleksandra Filipovska". University of Western Australia. Retrieved 14 August 2014.
  3. Rodgers, Anika. "Efforts to uncover Mitochondria's secrets increased". News: Health and Medicine. Science Network, Western Australia. Retrieved 8 August 2014.
  4. Bam Creative. "Professor Aleksandra Filipovska - Harry Perkins Institute of Medical Research". www.perkins.org.au. Retrieved 2019-08-14.
  5. "Scientific and Medical Advisory Panel". Australian Mitochondrial Disease Foundation. Retrieved 14 August 2014.
  6. "The 2014 Merck Millipore Research Medal: Aleksandra Filipovska". Australian Society for Biochemistry and Molecular Biology. Archived from the original on 14 August 2014. Retrieved 14 August 2014.
  7. "Researchers find link to failing heart in Muscular Dystrophy". Harry Perkins Institute of Medical Research. Retrieved 8 August 2014.
  8. Viola, HM; Adams, AM; Davis, SM; Fletcher, S; Filipovska, A; Hool, LC (2014). "Impaired functional communication between the L-type calcium channel and mitochondria contributes to metabolic inhibition in the mdx heart" (PDF). Proc Natl Acad Sci U S A. 111 (28): E2905–14. doi:10.1073/pnas.1402544111. PMC 4104855. PMID 24969422.
  9. Dean, Tim (16 January 2013). "Life scientists recognised in Australian Academy of Science awards". Australian Life Scientist. Retrieved 14 August 2014.
  10. Dr Aleksandra Filipovska. "2011 WA Tall Poppy Award Winners". Australian Institute of Science and Policy. Retrieved 14 August 2014.
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