Alicia Bertone

Alicia L. Bertone is an American academic, researcher, and veterinary surgeon. She is a Vice-Provost of Graduate Studies and holds the ENGIE-Axium Endowed Dean's Chair of the Graduate School at the Ohio State University.[1] Bertone is a Professor of Veterinary Clinical Sciences, and, as the Trueman Endowed Chair, established and directed the Comparative Orthopedic Research Laboratory at the University.[2]

Alicia L. Bertone
Born (1956-09-03) September 3, 1956
New York U.S.A.
NationalityAmerican
OccupationAcademic, researcher, and veterinary surgeon
TitleENGIE-Axium Endowed Dean’s Chair
Academic background
EducationB.S., Life Sciences
D.V.M., Veterinary Medicine
M.S., Pathology
Ph.D., Biomedical Sciences
Alma materCornell University
Colorado State University
Academic work
InstitutionsThe Ohio State University

Focusing clinically on orthopedic surgery, Bertone has published over 185 research papers regarding comparative orthopedic medicine, regenerative medicine, and gene therapy for the treatment of cartilage injury and bone repair. She is affiliated with Comparative Orthopedic Research Laboratory which focuses on the progressive translation of basic science in the area of molecular engineering, cell therapy, ortho-biologic therapies, as well as preclinical and clinical large animal models of regenerative orthopedics. She designed and patented the first commercial equine microarray.[3] Bertone is associated with Orthopaedic Research Society and made Panel Contributions to Pfizer Global Research and Development, European Veterinary Orthopedic Society, and British Equine Veterinary Association.[4][5]

Bertone is a Board Member of the Orthopedic Foundation[6] and is an active member of Ohio State and CVM research initiatives, such as founder of the Consortium for the Advancement of Neuromusculoskeletal Science and Locomotion.[7]

Education

Bertone started her initial education in the Fine Arts at the School of American Ballet in New York and later transitioned to the sciences. She studied at Cornell University and received her B.S. degree in Life Sciences with Honors, and her D.V.M degree, in 1977 and 1982, respectively. She was then enrolled at Colorado State University where she completed her M.S. degree in Pathology in 1986, and her Ph.D. degree in Biomedical Sciences the following year.[8] In 2001, Bertone completed an NIH Fellowship at Harvard in Gene Therapy from the Center for Molecular Orthopaedics.[1]

Career

Following her doctoral studies, Bertone taught briefly at Louisiana State University as an Assistant Professor of Clinical Sciences before joining Ohio State University's College of Veterinary Medicine in 1989 as an Assistant Professor of Veterinary Clinical Sciences. She was promoted to Associate Professor in 1993, and became a Professor in 1997. She is also associated with the University's Department of Orthopedics as an Adjunct Professor.[2]

Bertone has also held several administrative and clinical appointments. At Ohio State University, she was appointed as the Trueman Family Endowed Chair at College of Veterinary Medicine for two consecutive terms.[9] From 2007 till 2013, she directed the Industry Research at OSU Sports Medicine Center, and was appointed as Chair of the Post-professional Education Committee in 2011.[1]

Bertone was elected to the President's & Provost's Leadership Institute in 2017.[10] She is a Vice-Provost of Graduate Studies. Bertone also holds the ENGIE-Axium Endowed Dean's Chair.[1]

Bertone served as a member of Board of Regents for American College of Veterinary Surgery from 2008 till 2011, and is a Veterinary Delegate for the Federation Equestrian Internationale since 2013.[1]

Research

Bertone specializes in equine orthopedics, sports medicine and the science of orthopedic regenerative medicine. She has published over 185 research papers regarding comparative orthopedic medicine, regenerative medicine, and gene therapy for the treatment of cartilage injury and bone repair.[3]

Gene and stem cell therapy for bone repair and cartilage injury

Bertone along with her Ph.D. students, studied the use of genetically-engineered synovial transplants to induce a local anabolic effect on cartilage healing in vitro and in vivo. This approach is readily translatable to an arthroscopic delivery.[11] She and her colleagues, studied a pharmacologic approach to reduction of bone pain and inflammation at the cellular and immunological level.[12] Bertone also discovered low percentage of genetically-engineered cells needed for robust cartilage generation.[13]

Bertone studied the healing of rabbit bilateral ulnar osteotomies after surgery, in response to percutaneous injection of transgenic adenoviral (Ad) bone morphogenetic protein‐6 (BMP‐6) vector. She found BMP‐6 to be osteo-inductive in vivo resulting in acceleration of bone repair.[14] She conducted a study to investigate the feasibility of osteogenic differentiation of bone marrow–derived mesenchymal stem cells using two BMP genes and 3D alginate culture systems. Her research indicated that transduction of BMDMSC with bone morphogenetic proteins‐2 or ‐6 can accelerate osteogenic differentiation and mineralization of stem cells in culture.[15] She also achieved the repair of articular fractures in vivo using direct stem cell injection transduced with BMP-2,[16] however, the treatment was found to be insufficient to provide long-term quality osteochondral repair.[17]

Joint disease

Bertone published a clinical trial which served as a landmark paper reporting the high bar for FDA regulatory standards in veterinary medicine.[18] She investigated the joint, lymphnode, and PBMC response to non-autologous joint injections of non-engineered and engineered stem cells.[19] In 2007, Bertone published one of the first papers to show that molecularly engineered stem cells could regenerate cartilage in vivo.[16] She also completed clinical trials of autologous cell and platelet therapy in both dogs and horses.[20][21]

Bertone studied the response of equine joint after a repetitive injury and the rest period along with the physiological processes involved in the repairing of the damage. She highlighted the changes and complex interactions within the joint during the inflammatory process, and the available therapeutic modalities.[22] She conducted study to evaluate various synovial fluid cytokines and eicosanoids for the diagnosis of joint disease and categories of joint disease. She found interleukin‐6 to be an efficient screening test for the presence of joint disease when lameness is difficult to identify.[23] Bertone conducted randomized controlled clinical trials to compare efficacy of firocoxib and phenylbutazone paste formulations in horses with osteoarthritis, and found comparable efficacies of both drugs.[24] She published a paper in early 2010s regarding the reduction in interleukin-1β (IL-1β) signaling by RNA interference-based transcript reduction and receptor blockade method, and the quantification of changes incurred on transcript expression of additional mediators. She provided evidence for the in vivo role of IL-1β in spontaneous osteoarthritis.[25]

Awards/honors
  • 2004 - Pfizer Research Award, College of Veterinary Medicine, The Ohio State University
  • 2014 - Charles C. Capen Teaching Excellence Award for Graduate Education, OSUCVM[26]
  • 2017 - President's and Provost's Advisory Council on Women, The Ohio State University[10]

Bibliography
  • Palmer, J. L., & Bertone, A. L. (1994). Joint structure, biochemistry and biochemical disequilibrium in synovitis and equine joint disease. Equine veterinary journal, 26(4), 263–277.
  • Bertone, A. L., Palmer, J. L., & Jones, J. (2001). Synovial fluid cytokines and eicosanoids as markers of joint disease in horses. Veterinary Surgery, 30(6), 528–538.
  • Waselau, M., Sutter, W. W., Genovese, R. L., & Bertone, A. L. (2008). Intralesional injection of platelet-rich plasma followed by controlled exercise for treatment of midbody suspensory ligament desmitis in Standardbred racehorses. Journal of the American Veterinary Medical Association, 232(10), 1515–1520.
  • Santangelo, K., Nuovo, G. J., & Bertone, A. L. (2012). In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis. Osteoarthritis and cartilage, 20(12), 1610–1618.

References
  1. "Dr. Alicia Bertone is appointed Vice Provost for Graduate Studies and Dean of the Graduate School at Ohio State".
  2. "Alicia L. Bertone, DVM, PhD Diplomate ACVS, ACVSMR".
  3. "Alicia L Bertone". scholar.google.com.
  4. "Alicia L. Bertone, DVM, PhD, DACVS".
  5. "Consortium for Advancement of Neuromusculoskeletal (NMS) Science and Locomotion (CANSL): Regeneration & Recovery (R&R)- A-1" (PDF).
  6. "Self Serve Portal". online.acvs.org.
  7. "Consortium for Advancement of Neuromusculoskeletal (NMS) Science and Locomotion (CANSL): Regeneration & Recovery (R&R)- A-1" (PDF).
  8. "OSU professor doesn't feel saddled by job helping horses". The Lantern. March 9, 1999.
  9. "New Ohio Laboratory to Benefit Horses, Humans, and Other Species". The Horse. August 1, 2002.
  10. "Dr. Alicia Bertone Appointed to the President's and Provost's Council on Women".
  11. Reisbig, Nathalie A.; Pinnell, Erin; Scheuerman, Logan; Hussein, Hayam; Bertone, Alicia L. (January 8, 2019). "Synovium extra cellular matrices seeded with transduced mesenchymal stem cells stimulate chondrocyte maturation in vitro and cartilage healing in clinically-induced rat-knee lesions in vivo". PLOS ONE. 14 (3): e0212664. Bibcode:2019PLoSO..1412664R. doi:10.1371/journal.pone.0212664. PMC 6414009. PMID 30861010 – via PubMed.
  12. Hussein, Hayam; Boyaka, Prosper; Dulin, Jennifer; Russell, Duncan; Smanik, Lauren; Azab, Mohamed; Bertone, Alicia L. (January 8, 2017). "Cathepsin K Localizes to Equine Bone In Vivo and Inhibits Bone Marrow Stem and Progenitor Cells Differentiation In Vitro". Journal of Stem Cells & Regenerative Medicine. 13 (2): 45–53. doi:10.46582/jsrm.1302008. PMC 5786646. PMID 29391749 – via PubMed.
  13. Ng, Vincent Y.; Jump, Seth S.; Santangelo, Kelly S.; Russell, Duncan S.; Bertone, Alicia L. (January 1, 2013). "Genetic Engineering of Juvenile Human Chondrocytes Improves Scaffold-free Mosaic Neocartilage Grafts". Clinical Orthopaedics and Related Research. 471 (1): 26–38. doi:10.1007/s11999-012-2615-x. PMC 3528904. PMID 23008026 – via Springer Link.
  14. Bertone, A. L.; Pittman, D. D.; Bouxsein, M. L.; Li, J.; Clancy, B.; Seeherman, H. J. (2004). "Adenoviral‐mediated transfer of human BMP‐6 gene accelerates healing in a rabbit ulnar osteotomy model". Journal of Orthopaedic Research. 22 (6): 1261–1270. doi:10.1016/j.orthres.2004.03.014. PMID 15475207. S2CID 20793369.
  15. Zachos, Terri A.; Shields, Kathleen M.; Bertone, Alicia L. (2006). "Gene‐mediated osteogenic differentiation of stem cells by bone morphogenetic proteins‐2 or ‐6". Journal of Orthopaedic Research. 24 (6): 1279–1291. doi:10.1002/jor.20068. PMID 16649180. S2CID 31060102.
  16. Zachos, Terri; Diggs, Alisha; Weisbrode, Steven; Bartlett, Jeffrey; Bertone, Alicia (August 1, 2007). "Mesenchymal Stem Cell-mediated Gene Delivery of Bone Morphogenetic Protein-2 in an Articular Fracture Model". Molecular Therapy. 15 (8): 1543–1550. doi:10.1038/sj.mt.6300192. PMID 17519894 – via www.sciencedirect.com.
  17. Menendez, M.I.; Clark, D.J.; Carlton, M.; Flanigan, D.C.; Jia, G.; Sammet, S.; Weisbrode, S.E.; Knopp, M.V.; Bertone, A.L. (August 1, 2011). "Direct delayed human adenoviral BMP-2 or BMP-6 gene therapy for bone and cartilage regeneration in a pony osteochondral model". Osteoarthritis and Cartilage. 19 (8): 1066–1075. doi:10.1016/j.joca.2011.05.007. PMID 21683796 – via www.sciencedirect.com.
  18. Bertone, Alicia L.; Reisbig, Nathalie A.; Kilborne, Allison H.; Kaido, Mari; Salmanzadeh, Navid; Lovasz, Rebecca; Sizemore, Joy L.; Scheuermann, Logan; Kopp, Rosalind J.; Zekas, Lisa J.; Brokken, Matthew T. (January 8, 2017). "Equine Dental Pulp Connective Tissue Particles Reduced Lameness in Horses in a Controlled Clinical Trial". Frontiers in Veterinary Science. 4: 31. doi:10.3389/fvets.2017.00031. PMC 5344919. PMID 28344975.
  19. Pigott, John H.; Ishihara, Akikazu; Wellman, Maxey L.; Russell, Duncan S.; Bertone, Alicia L. (November 15, 2013). "Investigation of the immune response to autologous, allogeneic, and xenogeneic mesenchymal stem cells after intra-articular injection in horses". Veterinary Immunology and Immunopathology. 156 (1): 99–106. doi:10.1016/j.vetimm.2013.09.003. PMID 24094688 – via ScienceDirect.
  20. Fahie, Maria A.; Ortolano, Girolamo A.; Guercio, Vincent; Schaffer, Jeffrey A.; Johnston, Gary; Au, Jennifer; Hettlich, Bianca A.; Phillips, Tom; Allen, Matthew J.; Bertone, Alicia L. (October 17, 2013). "A randomized controlled trial of the efficacy of autologous platelet therapy for the treatment of osteoarthritis in dogs". Journal of the American Veterinary Medical Association. 243 (9): 1291–1297. doi:10.2460/javma.243.9.1291. PMID 24134578 – via avmajournals.avma.org (Atypon).
  21. Bertone, Alicia L.; Ishihara, Akikazu; Zekas, Lisa J.; Wellman, Maxey L.; Lewis, Katharine B.; Schwarze, Rebecca A.; Barnaba, Andrea R.; Schmall, Michael L.; Kanter, Peter M.; Genovese, Ron L. (January 28, 2014). "Evaluation of a single intra-articular injection of autologous protein solution for treatment of osteoarthritis in horses". American Journal of Veterinary Research. 75 (2): 141–151. doi:10.2460/ajvr.75.2.141. PMID 24471750 – via avmajournals.avma.org (Atypon).
  22. Palmer, JAN L.; Bertone, Alicia L. (1994). "Joint structure, biochemistry and biochemical disequilibrium in synovitis and equine joint disease". Equine Veterinary Journal. 26 (4): 263–277. doi:10.1111/j.2042-3306.1994.tb04386.x. PMID 8575393.
  23. "Synovial Fluid Cytokines and Eicosanoids as Markers of Joint Disease in Horses". doi:10.1053/jvet.2001. Cite journal requires |journal= (help)
  24. Doucet, Michèle Y.; Bertone, Alicia L.; Hendrickson, Dean; Hughes, Faith; MacAllister, Charles; McClure, Scott; Reinemeyer, Craig; Rossier, Yves; Sifferman, Roger; Vrins, André A.; White, Gary; Kunkle, Bruce; Alva, Roberto; Romano, Davida; Hanson, Peter D. (2008). "Comparison of efficacy and safety of paste formulations of firocoxib and phenylbutazone in horses with naturally occurring osteoarthritis". Journal of the American Veterinary Medical Association. 232 (1): 91–97. doi:10.2460/javma.232.1.91. PMID 18167116.
  25. Santangelo, K.S.; Nuovo, G.J.; Bertone, A.L. (December 1, 2012). "In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis". Osteoarthritis and Cartilage. 20 (12): 1610–1618. doi:10.1016/j.joca.2012.08.011. PMC 3478416. PMID 22935786.
  26. "Charles C. Capen Teaching Excellence Award for Graduate Education".
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