Annexin A4

Annexin A4 is a protein that in humans is encoded by the ANXA4 gene.[5][6]

ANXA4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesANXA4, ANX4, HEL-S-274, PIG28, ZAP36, P32.5, PAP-II, PP4-X, annexin A4
External IDsOMIM: 106491 MGI: 88030 HomoloGene: 68164 GeneCards: ANXA4
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p13.3Start69,644,425 bp[1]
End69,827,112 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

307

11746

Ensembl

ENSG00000196975

ENSMUSG00000029994

UniProt

P09525

P97429

RefSeq (mRNA)

NM_001153
NM_001320698
NM_001320700
NM_001320702
NM_001365496

NM_013471
NM_001331120

RefSeq (protein)

NP_001144
NP_001307627
NP_001307629
NP_001307631
NP_001352425

NP_001318049
NP_038499

Location (UCSC)Chr 2: 69.64 – 69.83 MbChr 6: 86.74 – 86.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000196975 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029994 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tait JF, Smith C, Frankenberry DA, Miao CH, Adler DA, Disteche CM (Feb 1992). "Chromosomal mapping of the human annexin IV (ANX4) gene". Genomics. 12 (2): 313–8. doi:10.1016/0888-7543(92)90379-7. PMID 1346776.
  6. "Entrez Gene: ANXA4 annexin A4".

Further reading


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