Anti-tetanus immunoglobulin

Anti-tetanus immunoglobulin, also known as tetanus immune globulin (TIG) and tetanus antitoxin, is a medication made up of antibodies against the tetanus toxin.[1] It is used to prevent tetanus in those who have a wound that is at high risk and have not been fully vaccinated with tetanus toxoid.[1] It is also used to treat tetanus along with antibiotics and muscle relaxants.[1] It is given by injection into a muscle.[1]

Anti-tetanus immunoglobulin
A vintage single-dose bottle of tetanus antitoxin manufactured by Sächsisches Serumwerk Dresden (now GlaxoSmithKline)
Clinical data
Trade namesHyperTET S/D, others
Other namestetanus immune globulin, tetanus antitoxin
AHFS/Drugs.comMonograph
Routes of
administration		IM
Identifiers
ChemSpider
  • none

Common side effects include pain at the site of injection and fever.[1] Allergic reactions including anaphylaxis may rarely occur.[1] There is also a very low risk of the spread of infections such as viral hepatitis and HIV/AIDS with the human version.[1] Use during pregnancy is deemed acceptable.[2] It is made from either human or horse blood plasma.[1][3]

Use of the horse version became common in the 1910s, while the human version came into frequent use in the 1960s.[4] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[5] The human version may be unavailable in the developing world.[3] The horse version is not typically used in the developed world due to the risk of serum sickness.[6]

References
  1. "Tetanus Immune Globulin". The American Society of Health-System Pharmacists. Archived from the original on 9 January 2017. Retrieved 8 January 2017.
  2. "Tetanus immune globulin Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 9 January 2017. Retrieved 8 January 2017.
  3. International Encyclopedia of Public Health (2 ed.). Academic Press. 2016. p. 161. ISBN 9780128037089. Archived from the original on 2017-01-09.
  4. Plotkin, Stanley A.; Orenstein, Walter A.; Offit, Paul A. (2012). Vaccines. Elsevier Health Sciences. pp. 103, 757. ISBN 978-1455700905. Archived from the original on 2017-01-09.
  5. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  6. Fauci, Anthony S.; Braunwald, Eugene; Kasper, Dennis L.; Hauser, Stephen; Longo, Dan; Jameson, J. Larry; Loscalzo, Joseph (2008). Harrison's Principles of Internal Medicine, 17th Edition. McGraw Hill Professional. p. 773. ISBN 9780071641142. Archived from the original on 2017-01-09.
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