Area composita

The area composita is a special heart muscle specific mixed type adhering junction connecting single cardiomyocytes. They are responsible for the force transmission during muscle contraction and are believed to be the main component of the mammalian cardiac intercalated discs.[1][2][3][4] Area composita structures consist of typical desmosomal in addition to typical fascia adhaerens proteins, whereas in epithelia both molecular classes show distinct and mutual exclusive localizations and both structures are also well separated.

References

Franke, Werner W.; Borrmann, Carola M.; Grund, Christine; Pieperhoff, Sebastian (2006). "The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins". European Journal of Cell Biology. 85 (2): 69–82. doi:10.1016/j.ejcb.2005.11.003. PMID 16406610.
Pieperhoff, Sebastian; Franke, Werner W. (2007). "The area composita of adhering junctions connecting heart muscle cells of vertebrates – IV: Coalescence and amalgamation of desmosomal and adhaerens junction components – Late processes in mammalian heart development". European Journal of Cell Biology. 86 (7): 377–391. doi:10.1016/j.ejcb.2007.04.001. PMID 17532539.
Pieperhoff, Sebastian; Franke, Werner W. (2008). "The area composita of adhering junctions connecting heart muscle cells of vertebrates". European Journal of Cell Biology. 87 (7): 413–430. doi:10.1016/j.ejcb.2008.02.005. PMID 18420304.
Goossens, S.; Janssens, B.; Bonne, S.; De Rycke, R.; Braet, F.; Van Hengel, J.; Van Roy, F. (2007). "A unique and specific interaction between T-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs". Journal of Cell Science. 120 (12): 2126–2136. doi:10.1242/jcs.004713. PMID 17535849. S2CID 20243727.

Borrmann, Carola M.; Grund, Christine; Kuhn, Cäcilia; Hofmann, Ilse; Pieperhoff, Sebastian; Franke, Werner W. (2006). "The area composita of adhering junctions connecting heart muscle cells of vertebrates. II. Colocalizations of desmosomal and fascia adhaerens molecules in the intercalated disk". European Journal of Cell Biology. 85 (6): 469–485. doi:10.1016/j.ejcb.2006.02.009. PMID 16600422.
Waschke, Jens (2008). "The desmosome and pemphigus". Histochemistry and Cell Biology. 130: 21–54. doi:10.1007/s00418-008-0420-0. PMC 2413110. PMID 18386043.

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[Franke2006-1] Franke, Werner W.; Borrmann, Carola M.; Grund, Christine; Pieperhoff, Sebastian (2006). "The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins". European Journal of Cell Biology. 85 (2): 69–82. doi:10.1016/j.ejcb.2005.11.003. PMID 16406610.

[Pieperhoff2007-2] Pieperhoff, Sebastian; Franke, Werner W. (2007). "The area composita of adhering junctions connecting heart muscle cells of vertebrates – IV: Coalescence and amalgamation of desmosomal and adhaerens junction components – Late processes in mammalian heart development". European Journal of Cell Biology. 86 (7): 377–391. doi:10.1016/j.ejcb.2007.04.001. PMID 17532539.

[Pieperhoff2008-3] Pieperhoff, Sebastian; Franke, Werner W. (2008). "The area composita of adhering junctions connecting heart muscle cells of vertebrates". European Journal of Cell Biology. 87 (7): 413–430. doi:10.1016/j.ejcb.2008.02.005. PMID 18420304.

[Goossens2007-4] Goossens, S.; Janssens, B.; Bonne, S.; De Rycke, R.; Braet, F.; Van Hengel, J.; Van Roy, F. (2007). "A unique and specific interaction between T-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs". Journal of Cell Science. 120 (12): 2126–2136. doi:10.1242/jcs.004713. PMID 17535849. S2CID 20243727.