Asya Rolls

Rolls completed her undergraduate degree in Life Sciences at the Technion within the Israel Institute of Technology.[1] After she obtained a Bachelors of Science, Rolls stayed in the department of Physical Chemistry at the Israel Institute of Technology for her Master’s.[1]

Following her Master’s, Rolls pursued her graduate studies at the Weizmann Institute in Israel.[2] Rolls pursued research in neuroimmunology under the mentorship Michal Schwartz within the Department of Neuroscience and Ofer Lider in the Department of immunology.[1] Her graduate work focused on exploring how the immune system impacts neurogenesis and brain repair.[3] Rolls explored the role of Toll-like Receptors in neurogenesis and found that TLR2 and TLR4 play opposing roles in the proliferation of new hippocampal neurons.[4] TLR2 seemed to promote neurogenesis and TLR4 seemed to impair neurogenesis, all through MyD88 signalling.[4] Rolls then explored the neurogenesis in pregnancy, to understand by learning and memory impairments are common in pregnant women.[4]  Rolls completed her PhD in 2007.[1]

In 2008, Rolls received the Fulbright Scholarship which allowed her to pursue her postdoctoral training at Stanford University in Palo Alto, California.[1] She worked in the Department of Psychiatry under the mentorship of Luis de Lecea and Craig Heller , exploring the impact of sleep on brain homeostasis and memory.[1] Rolls first used optogenetics to dissect the role of sleep in memory consolidation.[5] By activating orexin neurons optogenetically, Rolls was able to fragment sleep after learning and found that this impacted memory the following day.[5] Interestingly, the memory impairment only occurred if the minimal unit of uninterrupted sleep was below 62% of the normal.[5] Rolls later explored the importance of sleep in fear memory consolidation.[6] She found that specifically preventing protein synthesis during sleep caused decreases in fear memory formation highlighting the role of sleep in memory consolidation.[6] To further show the impact that sleep can have on health, Rolls and her team explored the role of sleep in the engraftment and implantation of hematopoietic stem cells (HSCs) in mice.[7] They found that sleep deprivation significantly decreased the expression of suppressor of cytokine signalling gene which impaired the migration and homing of HSCs.[7] Their findings emphasized the importance of sleep in the success of bone marrow transplantation.[7]

In 2012, Rolls was appointed to group leader at the Technion at the Israel Institute of Technology.[1] She is now an assistant professor in the Rappaport Medical School and is the principal investigator of the Rolls Lab.[1] Roll’s lab explores the connection between the brain and the immune system.[1] She specifically focuses on how the biological mechanisms underlying emotions and cognition affect immune function and physical health.[3] One innovation that the Rolls Lab pioneered is the merging of DREADDs technology with CyTOyF mass-cytometry to enable the high resolution measurements of the immune system after neuronal stimulation and inhibition.[1] Rolls is a member of The Israel Young Academy.

• 2017 Howard Hughes Medical Investigator-Wellcome International Research Scholar[11]
• 2017 Krill Prize - Wolf Foundation[12]
• 2015-2019 FENS-Kavli Network of Excellence[3]
• 2017 Adelis Brain Research Award[13]
• 2010 NARSAD Young Investigator Award[14]
• 2009 Rothschild Postdoctoral Fellowship[15]
• 2009 Clore Foundation’s Women in Science Award[16]
• 2008 Fulbright Scholar[17]

• 2019 TEDx Technion - Understanding the Brain’s Role in Immunity[2]
• 2018 Scientific American Article - Could Brain Stimulation Slow Cancer?[18]
• 2013 Scientific American Mind Article - Faulty Sleep Mechansims Might Cause Trauma to Linger[19]
• 2012 Nature News Article “To Sleep, Perchance to Forget Fears” [20]
• 2011 Los Angeles Times “ Fragmented Sleep May Impair Memory, Learning”[21]

• Tamar L Ben-Shaanan, Maya Schiller, Hilla Azulay-Debby, Ben Korin, Nadia Boshnak, Tamar Koren, Maria Krot, Jivan Shakya, Michal A. Rahat,Fahed Hakim & Asya Rolls. (2018) Modulation of anti-tumor immunity by the brain’s reward system. Nature Communications[22]
• Korin B, Dubovik T, Rolls A. (2018) Mass cytometry analysis of immune cells in the brain. Nature Protocols [22]
• Korin B, Ben-Shaanan TL, Schiller M, Dubovik T, Azulay-Debby H, Boshnak NT, Koren T, Rolls A. (2017). High-dimensional, single-cell characterization of the brain’s immune compartment. Nature Neuroscience.[22]
• Ben-Shaanan T.L, Azulay-Debby H., Dubovik T., Starosvetsky E., Korin., Schiller M., Green NL, Admon Y., Hakim F., Shen-Orr S*., Rolls A*. (2016) Activation of the reward system boosts innate and adaptive immunity. Nature Medicine [22]
• Rolls A., Fang W*., Ibarra i*., Bonovien P., Colas D., Heller HC,. Weissman I., de Lecea L. (2015) Sleep Regulates Hematopoietic Stem Cell Trafficking. Nature Communications (*equal)[22]
• Rolls A., Makam M*., Kroeger D., Colas D., de Lecea L., Heller HC. (2013) Sleep to forget: context independent interference with fear during sleep.  Molecular Psychiatry (*equal)[22]
• Rolls A., Colas D, Adamantidis A, Carter M, Lanre-Amos T., Heller HC. de Lecea L. (2011) Optogenetic Disruption of Sleep Continuity Impairs Memory Consolidation. PNAS.[22]
• Shechter R, Baruch K, Schwartz M*, Rolls A. (2010) Touch gives new life: mechanosensation modulates spinal cord adult neurogenesis. Molecular Psychiatry [22]
• Rolls A., Shechter R.*, London A., Segev Y., Jacob-Hirsch J., Amariglio N., Rechavi G. & Schwartz M. (2008) A dual role for chondroitin sulfate proteoglycan in spinal cord repair PLoS Medicine[22]
• Rolls A., Schori H., London A. and Schwartz M. (2008) Decrease in hippocampal neurongenesis during pregnancy. Molecular Psychiatry[22]
• Rolls A., Shechter R.*, London A., Ziv Y., Ronen A., Levy R. and Schwartz M. (2007) Toll-like receptors modulate adult hippocampal neurogenesis. Nature Cell Biology[22]