August Bernthsen

Heinrich August Bernthsen (29 August 1855 – 26 November 1931) was a German chemist who was among the first to synthesize and study the structures of methylene blue and phenothiazine.

Bernthsen was born to Heinrich Friedrich and Anna Sybilla Terheggen in Krefeld, Prussia. He studied the natural sciences before studying chemistry at Bonn and Heidelberg. After studying under Robert Bunsen he became an assistant to August Kekule. He worked from 1883 at the University of Heidelberg and from 1887 he worked at the Badische Aniline and Iodafabrik factory. He developed a number of dyes, many of which were patented.[1][2][3][4] He also pioneered the synthesis of several chemicals including phenothiazine and methylene blue.[5][6][7]

References
  1. Bernthsen, August (1885). "Studien in der Methylenblaugruppe". Justus Liebig's Annalen der Chemie (in German). 230 (1): 73–136. doi:10.1002/jlac.18852300106.
  2. Bernthsen, August (1884). "Die Acridine". Justus Liebig's Annalen der Chemie (in German). 224 (1–2): 1–56. doi:10.1002/jlac.18842240102.
  3. Bernthsen, August; Semper, August (1887). "Ueber die Constitution des Juglons und seine Synthese aus Naphtalin". Berichte der Deutschen Chemischen Gesellschaft (in German). 20 (1): 934–941. doi:10.1002/cber.188702001213.
  4. Bernthsen, August; Bender, Fritz (1883). "Ueber die Bildung von Nitrilbasen aus organischen Säuren und Aminen; Synthese der Acridine". Berichte der Deutschen Chemischen Gesellschaft (in German). 16 (2): 1802–1819. doi:10.1002/cber.18830160261.
  5. Spagl, Rudolf (1955). "Bernthsen, August". Neue Deutsche Biographie. 2. p. 142.
  6. Ohlow, Maike J.; Moosmann, Bernd (2011). "Phenothiazine: the seven lives of pharmacology's first lead structure". Drug Discovery Today. 16 (3–4): 119–131. doi:10.1016/j.drudis.2011.01.001. PMID 21237283.
  7. Amaral, Leonard; Viveiros, Miguel (2017). "Thioridazine: A Non-Antibiotic Drug Highly Effective, in Combination with First Line Anti-Tuberculosis Drugs, against Any Form of Antibiotic Resistance of Mycobacterium tuberculosis Due to Its Multi-Mechanisms of Action". Antibiotics. 6 (1): 3. doi:10.3390/antibiotics6010003. ISSN 2079-6382. PMC 5372983. PMID 28098814.
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