CACYBP

Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene.[5][6][7]

CACYBP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCACYBP, GIG5, S100A6BP, SIP, PNAS-107, calcyclin binding protein
External IDsOMIM: 606186 MGI: 1270839 HomoloGene: 7649 GeneCards: CACYBP
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q25.1Start174,999,163 bp[1]
End175,012,027 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

27101

12301

Ensembl

ENSG00000116161

ENSMUSG00000014226

UniProt

Q9HB71

Q9CXW3

RefSeq (mRNA)

NM_014412
NM_001007214

NM_009786

RefSeq (protein)

NP_001007215
NP_055227

NP_033916

Location (UCSC)Chr 1: 175 – 175.01 MbChr 1: 160.2 – 160.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[7]

Protein Interactions

CACYBP has been shown to interact with SKP1A[8] and SIAH1.[5]

The CacyBP/SIP complex instead, is known to be a part of stress respons, since it interacts with chaperone HSP90.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000116161 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000014226 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Matsuzawa SI, Reed JC (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Molecular Cell. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. PMID 11389839.
  6. Matsuzawa S, Li C, Ni CZ, Takayama S, Reed JC, Ely KR (January 2003). "Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)". The Journal of Biological Chemistry. 278 (3): 1837–40. doi:10.1074/jbc.M210263200. PMID 12421809.
  7. "Entrez Gene: CACYBP calcyclin binding protein".
  8. Matsuzawa SI, Reed JC (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Molecular Cell. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. PMID 11389839.
  9. Filipek, Anna; Leśniak, Wiesława (2018-12-29). "Aktualny pogląd na komórkową funkcję S100A6 i jego ligandów, CacyBP/SIP i Sgt1". Postępy Biochemii (in Polish). 64 (3): 242–252. doi:10.18388/pb.2018_136. ISSN 0032-5422. PMID 30656909.

Further reading


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