CAP2

CAP2
Identifiers
Aliases	CAP2, CAP, adenylate cyclase-associated protein, 2 (yeast), cyclase associated actin cytoskeleton regulatory protein 2
External IDs	OMIM: 618385 MGI: 1914502 HomoloGene: 101397 GeneCards: CAP2
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	17,557,790 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	46,650,281 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • actin binding; • adenylate cyclase binding; • identical protein binding;
Cellular component	• cell membrane; • membrane; • cortical actin cytoskeleton; • GO:0097483, GO:0097481 postsynaptic density;
Biological process	• establishment or maintenance of cell polarity; • cytoskeleton organization; • signal transduction; • activation of adenylate cyclase activity; • actin polymerization or depolymerization; • cell morphogenesis; • regulation of adenylate cyclase activity;
	Sources:Amigo / QuickGO
Orthologs
	10486
	67252
	ENSG00000112186
	ENSMUSG00000021373
	P40123
	Q9CYT6
	NM_006366; NM_001363533; NM_001363534
	NM_026056
	NP_006357; NP_001350462; NP_001350463
	NP_080332
	Wikidata
View/Edit Human	View/Edit Mouse

Adenylyl cyclase-associated protein 2 is an enzyme that in humans is encoded by the CAP2 gene.[5][6][7]

Function

This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin.[7]

Interactions

CAP2 has been shown to interact with CAP1.[6]

References

GRCh38: Ensembl release 89: ENSG00000112186 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021373 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yu G, Swiston J, Young D (Jun 1994). "Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins". Journal of Cell Science. 107 (6): 1671–8. PMID 7962207.
Hubberstey A, Yu G, Loewith R, Lakusta C, Young D (Jun 1996). "Mammalian CAP interacts with CAP, CAP2, and actin". Journal of Cellular Biochemistry. 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. PMID 8761950.
"Entrez Gene: CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)".

External links

Human CAP2 genome location and CAP2 gene details page in the UCSC Genome Browser.

Shibata R, Mori T, Du W, Chuma M, Gotoh M, Shimazu M, Ueda M, Hirohashi S, Sakamoto M (Sep 2006). "Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis". Clinical Cancer Research. 12 (18): 5363–8. doi:10.1158/1078-0432.CCR-05-2245. PMID 17000669.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112186 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021373 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7962207-5] Yu G, Swiston J, Young D (Jun 1994). "Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins". Journal of Cell Science. 107 (6): 1671–8. PMID 7962207.

[pmid8761950-6] Hubberstey A, Yu G, Loewith R, Lakusta C, Young D (Jun 1996). "Mammalian CAP interacts with CAP, CAP2, and actin". Journal of Cellular Biochemistry. 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. PMID 8761950.

[entrez-7] "Entrez Gene: CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)".

CAP2

Function

Interactions

References

External links

Further reading