CBX2 (gene)

Chromobox protein homolog 2 is a protein that in humans is encoded by the CBX2 gene.[5][6][7] According to a New Scientist article CBX2 controls human sex even more so than X/Y chromosomes.[8]

CBX2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCBX2, CDCA6, M33, SRXY5, chromobox 2
External IDsOMIM: 602770 MGI: 88289 HomoloGene: 7256 GeneCards: CBX2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q25.3Start79,778,148 bp[1]
End79,787,983 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

84733

12416

Ensembl

ENSG00000173894

ENSMUSG00000025577

UniProt

Q14781

P30658

RefSeq (mRNA)

NM_005189
NM_032647

NM_007623

RefSeq (protein)

NP_005180
NP_116036

NP_031649

Location (UCSC)Chr 17: 79.78 – 79.79 MbChr 11: 119.02 – 119.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

CBX2 (gene) has been shown to interact with RYBP.[9] It also interacts with the testis determining factor encoded by the SRY gene on the Y chromosome, as both proteins are necessary components of the male cascade.

References
  1. GRCh38: Ensembl release 89: ENSG00000173894 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025577 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gecz J, Gaunt SJ, Passage E, Burton RD, Cudrey C, Pearce JJ, Fontes M (Jul 1995). "Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25". Genomics. 26 (1): 130–3. doi:10.1016/0888-7543(95)80091-Y. PMID 7782071.
  6. Chodak GW (Nov 1989). "Early detection and screening for prostatic cancer". Urology. 34 (4 Suppl): 10–2, discussion 46–56. doi:10.1016/0090-4295(89)90228-8. PMID 2477932.
  7. "Entrez Gene: CBX2 chromobox homolog 2 (Pc class homolog, Drosophila)".
  8. Ewen Callaway. "Girl with Y chromosome sheds light on maleness ", New Scientist, 2009-04-09. Retrieved on 2009-04-14.
  9. García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.

Further reading
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
  • Katoh-Fukui Y, Tsuchiya R, Shiroishi T, Nakahara Y, Hashimoto N, Noguchi K, Higashinakagawa T (1998). "Male-to-female sex reversal in M33 mutant mice". Nature. 393 (6686): 688–92. doi:10.1038/31482. PMID 9641679. S2CID 4399183.
  • Pearce JJ, Singh PB, Gaunt SJ (1992). "The mouse has a Polycomb-like chromobox gene". Development. 114 (4): 921–9. PMID 1352241.


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