CCT4

T-complex protein 1 subunit delta is a protein that in humans is encoded by the CCT4 gene.[4][5] The CCT4 protein is a component of the TRiC complex.

CCT4
Identifiers
AliasesCCT4, CCT-DELTA, Cctd, SRB, chaperonin containing TCP1 subunit 4
External IDsOMIM: 605142 MGI: 104689 HomoloGene: 4695 GeneCards: CCT4
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p15Start61,868,085 bp[1]
End61,888,671 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10575

12464

Ensembl

ENSG00000115484

ENSMUSG00000007739

UniProt

P50991

P80315

RefSeq (mRNA)

NM_006430
NM_001256721

NM_009837

RefSeq (protein)

NP_001243650
NP_006421

NP_033967

Location (UCSC)Chr 2: 61.87 – 61.89 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

CCT4 has been shown to interact with PPP4C.[6][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000115484 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT". Molecular and Cellular Biology. 18 (12): 7584–9. doi:10.1128/mcb.18.12.7584. PMC 109339. PMID 9819444.
  5. "Entrez Gene: CCT4 chaperonin containing TCP1, subunit 4 (delta)".
  6. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
  7. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity" (PDF). Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. S2CID 7531012.

Further reading


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