CCT5 (gene)

T-complex protein 1 subunit epsilon is a protein that in humans is encoded by the CCT5 gene.[5]

CCT5
Identifiers
AliasesCCT5, CCT-epsilon, CCTE, HEL-S-69, TCP-1-epsilon, PNAS-102, chaperonin containing TCP1 subunit 5
External IDsOMIM: 610150 MGI: 107185 HomoloGene: 6287 GeneCards: CCT5
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5p15.2Start10,249,929 bp[1]
End10,266,389 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

22948

12465

Ensembl

ENSG00000150753

ENSMUSG00000022234

UniProt

P48643

P80316

RefSeq (mRNA)

NM_001306153
NM_001306154
NM_001306155
NM_001306156
NM_012073

NM_007637
NM_001348035

RefSeq (protein)

NP_001293082
NP_001293083
NP_001293084
NP_001293085
NP_036205

NP_001334964
NP_031663

Location (UCSC)Chr 5: 10.25 – 10.27 MbChr 15: 31.59 – 31.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[5]

Interactions

CCT5 (gene) has been shown to interact with PPP4C.[6][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000150753 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022234 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CCT5 chaperonin containing TCP1, subunit 5 (epsilon)".
  6. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
  7. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity" (PDF). Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. S2CID 7531012.

Further reading


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