CDC16

Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene.[5][6]

CDC16
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDC16, ANAPC6, APC6, CUT9, CDC16Hs, cell division cycle 16
External IDsOMIM: 603461 MGI: 1917207 HomoloGene: 2899 GeneCards: CDC16
Gene location (Human)
Chr.Chromosome 13 (human)[1]
Band13q34Start114,234,887 bp[1]
End114,272,723 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8881

69957

Ensembl

ENSG00000130177

ENSMUSG00000038416

UniProt

Q13042

Q8R349

RefSeq (mRNA)

NM_027276
NM_001357247

RefSeq (protein)

NP_081552
NP_001344176

Location (UCSC)Chr 13: 114.23 – 114.27 MbChr 8: 13.76 – 13.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified.[6]

Interactions

CDC16 has been shown to interact with CDC27[7][8][9][10] and CDC20.[7][9][11][12]

References
  1. GRCh38: Ensembl release 89: ENSG00000130177 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038416 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tugendreich S, Tomkiel J, Earnshaw W, Hieter P (Apr 1995). "CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition". Cell. 81 (2): 261–8. doi:10.1016/0092-8674(95)90336-4. PMID 7736578. S2CID 17907584.
  6. "Entrez Gene: CDC16 cell division cycle 16 homolog (S. cerevisiae)".
  7. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
  8. Ollendorff V, Donoghue DJ (Dec 1997). "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex". The Journal of Biological Chemistry. 272 (51): 32011–8. doi:10.1074/jbc.272.51.32011. PMID 9405394.
  9. Kallio M, Weinstein J, Daum JR, Burke DJ, Gorbsky GJ (Jun 1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events". The Journal of Cell Biology. 141 (6): 1393–406. doi:10.1083/jcb.141.6.1393. PMC 2132789. PMID 9628895.
  10. Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
  11. Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ (Sep 2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". The Journal of Cell Biology. 158 (5): 841–7. doi:10.1083/jcb.200201135. PMC 2173153. PMID 12196507.
  12. Nilsson J, Yekezare M, Minshull J, Pines J (Dec 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nature Cell Biology. 10 (12): 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788.

Further reading
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