CGB2 (gene)

Choriogonadotropin subunit beta variant 2 is a protein that in humans is encoded by the CGB2 gene.[3][4]

CGB2
Identifiers
Aliases	CGB2, chorionic gonadotropin beta subunit 2, chorionic gonadotropin subunit beta 2
External IDs	OMIM: 608824 HomoloGene: 137643 GeneCards: CGB2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,031,912 bp[1] End 49,033,238 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • hormone activity Cellular component • extracellular region • extracellular • cytoplasm Biological process • G-protein coupled receptor signaling pathway • cell-cell signaling • hormone-mediated signaling pathway • ovulation • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114336	n/a
Ensembl	ENSG00000104818	n/a
UniProt	Q6NT52	n/a
RefSeq (mRNA)	NM_033378 NM_001319065	n/a
RefSeq (protein)	NP_001305994 NP_203696	n/a
Location (UCSC)	Chr 19: 49.03 – 49.03 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits.[5] However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.[4]