CHKA

Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene.[5][6][7]

CHKA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCHKA, CHK, CK, CKI, EK, choline kinase alpha
External IDsOMIM: 118491 MGI: 107760 HomoloGene: 88575 GeneCards: CHKA
EC number2.7.1.82
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.2Start68,052,859 bp[1]
End68,121,444 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1119

12660

Ensembl

ENSG00000110721

ENSMUSG00000024843

UniProt

P35790

O54804

RefSeq (mRNA)

NM_001025566
NM_001271496
NM_013490

RefSeq (protein)

NP_001258425
NP_038518

Location (UCSC)Chr 11: 68.05 – 68.12 MbChr 19: 3.85 – 3.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.[7]

In melanocytic cells CHKA gene expression may be regulated by MITF.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000110721 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024843 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hosaka K, Tanaka S, Nikawa J, Yamashita S (Aug 1992). "Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation". FEBS Lett. 304 (2–3): 229–32. doi:10.1016/0014-5793(92)80625-Q. PMID 1618328. S2CID 25275208.
  6. Aoyama C, Liao H, Ishidate K (Mar 2004). "Structure and function of choline kinase isoforms in mammalian cells". Prog Lipid Res. 43 (3): 266–81. doi:10.1016/j.plipres.2003.12.001. PMID 15003397.
  7. "Entrez Gene: CHKA choline kinase alpha".
  8. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Further reading


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