CLUAP1

Clusterin associated protein 1, also known as CLUAP1, is a human gene.[5]

CLUAP1
Identifiers
AliasesCLUAP1, CFAP22, FAP22, IFT38, clusterin associated protein 1
External IDsOMIM: 616787 MGI: 1924029 HomoloGene: 14831 GeneCards: CLUAP1
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p13.3Start3,500,976 bp[1]
End3,539,048 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23059

76779

Ensembl

ENSG00000103351

ENSMUSG00000014232

UniProt

Q96AJ1

Q8R3P7

RefSeq (mRNA)

NM_015041
NM_024793
NM_001330454

NM_029738

RefSeq (protein)

NP_001317383
NP_055856
NP_079069

NP_084014

Location (UCSC)Chr 16: 3.5 – 3.54 MbChr 16: 3.91 – 3.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of CLUAP1 function. A conditional knockout mouse line, called Cluap1tm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty six tests were carried out on mutant mice and four significant abnormalities were observed.[9] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; both sexes had decreased IgG1 levels while males also displayed abnormal spine curvature resulting in kyphosis.[9]

References
  1. GRCh38: Ensembl release 89: ENSG00000103351 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000014232 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: clusterin associated protein 1". Retrieved 2011-08-30.
  6. "Radiography data for Cluap1". Wellcome Trust Sanger Institute.
  7. "Salmonella infection data for Cluap1". Wellcome Trust Sanger Institute.
  8. "Citrobacter infection data for Cluap1". Wellcome Trust Sanger Institute.
  9. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  10. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. "International Knockout Mouse Consortium". Archived from the original on 2012-05-29. Retrieved 2012-02-14.
  12. "Mouse Genome Informatics".
  13. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. S2CID 39281705.
  15. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  16. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading
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