CNOT1

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

CCR4-Not complex component, Not1
Identifiers
Symbol	Not1
Pfam	PF04054
InterPro	IPR007196
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

CNOT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4C0D, 4CQO, 4CRV, 4CRW, 4CT4, 4CT6, 4CT7, 4GMJ, 4GML, 4J8S, 5ANR, 5FU6, 5FU7
Identifiers
Aliases	CNOT1, CDC39, NOT1, NOT1H, AD-005, CCR4-NOT transcription complex subunit 1, HPE12
External IDs	OMIM: 604917 MGI: 2442402 HomoloGene: 9453 GeneCards: CNOT1
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	58,629,885 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	95,807,464 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• poly(A)-specific ribonuclease activity; • protein domain specific binding; • GO:0001948 protein binding; • retinoic acid receptor binding; • armadillo repeat domain binding; • GO:0032947 molecular adaptor activity; • estrogen receptor binding; • RNA binding;
Cellular component	• membrane; • CCR4-NOT complex; • peroxisomal membrane; • P-body; • CCR4-NOT core complex; • cell nucleus; • extracellular; • cytoplasm; • cytosol;
Biological process	• nuclear-transcribed mRNA poly(A) tail shortening; • negative regulation of translation; • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; • regulation of transcription, DNA-templated; • negative regulation of retinoic acid receptor signaling pathway; • regulation of stem cell population maintenance; • negative regulation of transcription from RNA polymerase II promoter; • positive regulation of mRNA catabolic process; • transcription, DNA-templated; • multicellular organism development; • positive regulation of cytoplasmic mRNA processing body assembly; • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; • gene silencing by miRNA; • gene silencing by RNA; • negative regulation of intracellular estrogen receptor signaling pathway; • regulation of translation; • RNA phosphodiester bond hydrolysis, exonucleolytic; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
	Sources:Amigo / QuickGO
Orthologs
	23019
	234594
	ENSG00000125107
	ENSMUSG00000036550
	A5YKK6; H3BNB1
	Q6ZQ08
	NM_001265612; NM_016284; NM_206999
	NM_001205226; NM_153164; NM_178078; NM_001372351; NM_001372353
	NP_001252541; NP_057368; NP_996882
	NP_001192155; NP_694804; NP_835179; NP_001359280; NP_001359282
	Wikidata
View/Edit Human	View/Edit Mouse

CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.[5][6]

It is a part of the CCR4-Not complex, which deadenylates mRNAs.[7] CNOT1 acts as a scaffold protein, binding other subunits of the complex.[8][9][10]

Interactions

CNOT1 has been shown to interact with CNOT8.[11][12]

References

GRCh38: Ensembl release 89: ENSG00000125107 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000036550 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
"Entrez Gene: CNOT1 CCR4-NOT transcription complex, subunit 1".
Garneau NL, Wilusz J, Wilusz CJ (Feb 2007). "The highways and byways of mRNA decay". Nat. Rev. Mol. Cell Biol. 8 (2): 113–26. doi:10.1038/nrm2104. PMID 17245413. S2CID 14107577.
Sandler H, Kreth J, Timmers HT, Stoecklin G (May 2011). "Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin". Nucleic Acids Res. 39 (10): 4373–86. doi:10.1093/nar/gkr011. PMC 3105394. PMID 21278420.
Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O (Nov 2012). "The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex". Nucleic Acids Res. 40 (21): 11058–72. doi:10.1093/nar/gks883. PMC 3510486. PMID 22977175.
Basquin J, Roudko VV, Rode M, Basquin C, Séraphin B, Conti E (Oct 26, 2012). "Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction". Mol. Cell. 48 (2): 207–18. doi:10.1016/j.molcel.2012.08.014. PMID 22959269.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (February 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

External links

Eukaryotic Linear Motif resource motif class LIG_CNOT1_NIM_1
Human CNOT1 genome location and CNOT1 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: A5YKK6 (CCR4-NOT transcription complex subunit 1) at the PDBe-KB.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125107 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036550 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14702039-5] Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

[entrez-6] "Entrez Gene: CNOT1 CCR4-NOT transcription complex, subunit 1".

[7] Garneau NL, Wilusz J, Wilusz CJ (Feb 2007). "The highways and byways of mRNA decay". Nat. Rev. Mol. Cell Biol. 8 (2): 113–26. doi:10.1038/nrm2104. PMID 17245413. S2CID 14107577.

[8] Sandler H, Kreth J, Timmers HT, Stoecklin G (May 2011). "Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin". Nucleic Acids Res. 39 (10): 4373–86. doi:10.1093/nar/gkr011. PMC 3105394. PMID 21278420.

[9] Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O (Nov 2012). "The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex". Nucleic Acids Res. 40 (21): 11058–72. doi:10.1093/nar/gks883. PMC 3510486. PMID 22977175.

[10] Basquin J, Roudko VV, Rode M, Basquin C, Séraphin B, Conti E (Oct 26, 2012). "Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction". Mol. Cell. 48 (2): 207–18. doi:10.1016/j.molcel.2012.08.014. PMID 22959269.

[pmid17353931-11] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid10637334-12] Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (February 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

CNOT1

Interactions

References

Further reading

External links