COG2

Conserved oligomeric Golgi complex subunit 2 is a protein that in humans is encoded by the COG2 gene.[5][6] Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG2 (Ungar et al., 2002).[6]

COG2
Identifiers
AliasesCOG2, LDLC, component of oligomeric golgi complex 2, CDG2Q
External IDsOMIM: 606974 MGI: 1923582 HomoloGene: 7206 GeneCards: COG2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q42.2Start230,642,481 bp[1]
End230,693,982 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

22796

76332

Ensembl

ENSG00000135775

ENSMUSG00000031979

UniProt

Q14746

Q921L5

RefSeq (mRNA)

NM_007357
NM_001145036

NM_029746

RefSeq (protein)

NP_001138508
NP_031383

NP_084022

Location (UCSC)Chr 1: 230.64 – 230.69 MbChr 8: 124.52 – 124.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of COG2 function. A conditional knockout mouse line, called Cog2tm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty five were carried out on mutant mice and one significant abnormality was observed: no homozygous mutant mice survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.[9]

Interactions

COG2 has been shown to interact with COG4[17] and COG3.[18]

References

  1. GRCh38: Ensembl release 89: ENSG00000135775 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031979 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Podos SD, Reddy P, Ashkenas J, Krieger M (Dec 1994). "LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function". J Cell Biol. 127 (3): 679–91. doi:10.1083/jcb.127.3.679. PMC 2120235. PMID 7962052.
  6. "Entrez Gene: COG2 component of oligomeric golgi complex 2".
  7. "Salmonella infection data for Cog2". Wellcome Trust Sanger Institute.
  8. "Citrobacter infection data for Cog2". Wellcome Trust Sanger Institute.
  9. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  10. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. "International Knockout Mouse Consortium".
  12. "Mouse Genome Informatics".
  13. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  15. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  16. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
  17. Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.
  18. Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878.

Further reading

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