COP9 signalosome complex subunit 3

COPS3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D10, 4D18, 4WSN
Identifiers
Aliases	COPS3, CSN3, SGN3, COP9 signalosome subunit 3
External IDs	OMIM: 604665 MGI: 1349409 HomoloGene: 2710 GeneCards: COPS3
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	17,281,273 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	59,839,838 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding;
Cellular component	• COP9 signalosome; • cell nucleus; • nucleoplasm; • cytoplasm; • cytosol;
Biological process	• transcription-coupled nucleotide-excision repair; • in utero embryonic development; • ubiquitin-dependent protein catabolic process; • nucleotide-excision repair, DNA damage recognition; • signal transduction; • response to light stimulus; • protein deneddylation; • post-translational modification;
	Sources:Amigo / QuickGO
Orthologs
	8533
	26572
	ENSG00000141030
	ENSMUSG00000019373
	Q9UNS2
	O88543
NM_001199125; NM_003653; NM_001316354; NM_001316355; NM_001316356;
	NM_001316357; NM_001316358
	NM_011991
NP_001186054; NP_001303283; NP_001303284; NP_001303285; NP_001303286;
	NP_001303287; NP_003644
	NP_036121
	Wikidata
View/Edit Human	View/Edit Mouse

COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene.[5][6][7] It encodes a subunit of the COP9 signalosome.

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[7]

References

GRCh38: Ensembl release 89: ENSG00000141030 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019373 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi:10.1096/fasebj.12.6.469. PMID 9535219. S2CID 25424324.
Potocki L, Chen KS, Lupski JR (Jun 1999). "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2". Genomics. 57 (1): 180–2. doi:10.1006/geno.1998.5748. PMID 10191102.
"Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)".

External links

Human COPS3 genome location and COPS3 gene details page in the UCSC Genome Browser.
Human CSN3 genome location and CSN3 gene details page in the UCSC Genome Browser.

Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. doi:10.1038/ncb1203-1029. PMID 14647295. S2CID 37458780.
van Dartel M, Hulsebos TJ (2004). "Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma". Cancer Genet. Cytogenet. 153 (1): 77–80. doi:10.1016/j.cancergencyto.2004.03.007. PMID 15325100.
Wei N, Tsuge T, Serino G, et al. (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr. Biol. 8 (16): 919–22. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402. S2CID 13873982.
Bianchi E, Denti S, Granata A, et al. (2000). "Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity". Nature. 404 (6778): 617–21. doi:10.1038/35007098. PMID 10766246. S2CID 4384395.
Tsuge T, Matsui M, Wei N (2001). "The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain". J. Mol. Biol. 305 (1): 1–9. doi:10.1006/jmbi.2000.4288. PMID 11114242.
Bech-Otschir D, Kraft R, Huang X, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMC 145508. PMID 11285227.
Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588. S2CID 14224920.
Hong X, Xu L, Li X, et al. (2001). "CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation". FEBS Lett. 499 (1–2): 133–6. doi:10.1016/S0014-5793(01)02535-2. PMID 11418127. S2CID 85296851.
Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594. PMID 11997338.
Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2. PMID 12220626. S2CID 39308598.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Petersen HH, Hilpert J, Militz D, et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell Sci. 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. PMID 12508107.
Serino G, Su H, Peng Z, et al. (2003). "Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex". Plant Cell. 15 (3): 719–31. doi:10.1105/tpc.009092. PMC 150025. PMID 12615944.
Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
Uhle S, Medalia O, Waldron R, et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. doi:10.1093/emboj/cdg127. PMC 151059. PMID 12628923.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Groisman R, Polanowska J, Kuraoka I, et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–67. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143. S2CID 11639677.
Henriksen J, Aagesen TH, Maelandsmo GM, et al. (2003). "Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation". Oncogene. 22 (34): 5358–61. doi:10.1038/sj.onc.1206671. PMID 12917637.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141030 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019373 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9535219-5] Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi:10.1096/fasebj.12.6.469. PMID 9535219. S2CID 25424324.

[pmid10191102-6] Potocki L, Chen KS, Lupski JR (Jun 1999). "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2". Genomics. 57 (1): 180–2. doi:10.1006/geno.1998.5748. PMID 10191102.

[entrez-7] "Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)".

COP9 signalosome complex subunit 3

See also

References

External links

Further reading