COP9 signalosome complex subunit 3

COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene.[5][6][7] It encodes a subunit of the COP9 signalosome.

COPS3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOPS3, CSN3, SGN3, COP9 signalosome subunit 3
External IDsOMIM: 604665 MGI: 1349409 HomoloGene: 2710 GeneCards: COPS3
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p11.2Start17,246,616 bp[1]
End17,281,273 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8533

26572

Ensembl

ENSG00000141030

ENSMUSG00000019373

UniProt

Q9UNS2

O88543

RefSeq (mRNA)

NM_011991

RefSeq (protein)

NP_036121

Location (UCSC)Chr 17: 17.25 – 17.28 MbChr 11: 59.82 – 59.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000141030 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019373 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi:10.1096/fasebj.12.6.469. PMID 9535219. S2CID 25424324.
  6. Potocki L, Chen KS, Lupski JR (Jun 1999). "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2". Genomics. 57 (1): 180–2. doi:10.1006/geno.1998.5748. PMID 10191102.
  7. "Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)".

Further reading


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