COPS4

COP9 signalosome complex subunit 4 is a protein that in humans is encoded by the COPS4 gene.[5][6]

COPS4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOPS4, CSN4, COP9 signalosome subunit 4, SGN4
External IDsOMIM: 616008 MGI: 1349414 HomoloGene: 8067 GeneCards: COPS4
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q21.22Start83,034,447 bp[1]
End83,075,818 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51138

26891

Ensembl

ENSG00000138663

ENSMUSG00000035297

UniProt

Q9BT78

O88544

RefSeq (mRNA)

NM_001258006
NM_016129
NM_001330727

NM_012001
NM_001359203
NM_001359204

RefSeq (protein)

NP_001244935
NP_001317656
NP_057213

NP_036131
NP_001346132
NP_001346133

Location (UCSC)Chr 4: 83.03 – 83.08 MbChr 5: 100.52 – 100.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000138663 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035297 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW (Oct 1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr Biol. 8 (16): 919–924. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402. S2CID 13873982.
  6. "Entrez Gene: COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)".

Further reading


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