COX7A2L

Cytochrome c oxidase subunit 7A-related protein, mitochondrial is an enzyme that in humans is encoded by the COX7A2L gene.[5][6]

COX7A2L
Identifiers
AliasesCOX7A2L, COX7AR, COX7RP, EB1, SIG81, cytochrome c oxidase subunit 7A2 like
External IDsOMIM: 605771 MGI: 106015 HomoloGene: 3463 GeneCards: COX7A2L
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p21Start42,333,546 bp[1]
End42,425,088 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9167

20463

Ensembl

ENSG00000115944

ENSMUSG00000024248

UniProt

O14548

Q61387

RefSeq (mRNA)

NM_004718
NM_001319036
NM_001319037
NM_001319038
NM_001319040

NM_001159529
NM_009187

RefSeq (protein)

NP_001305965
NP_001305966
NP_001305967
NP_001305969
NP_004709

NP_001153001
NP_033213

Location (UCSC)Chr 2: 42.33 – 42.43 MbChr 17: 83.5 – 83.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes.

The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex.

This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence.

This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000115944 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024248 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Watanabe T, Inoue S, Hiroi H, Orimo A, Kawashima H, Muramatsu M (Jan 1998). "Isolation of estrogen-responsive genes with a CpG island library". Mol Cell Biol. 18 (1): 442–9. doi:10.1128/mcb.18.1.442. PMC 121513. PMID 9418891.
  6. "Entrez Gene: COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like".

Further reading


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