Calcium citrate malate

Calcium citrate malate[1]
Identifiers
CAS Number	142606-53-9 ;
3D model (JSmol)	Interactive image;
ECHA InfoCard	100.127.532
EC Number	604-299-4;
PubChem CID	86746885; 92043277;
UNII	4BBS3A53GJ ;
CompTox Dashboard (EPA)	DTXSID00931542 ;
	InChI InChI=1S/C10H12O11.C6H8O7.3Ca/c11-4(1-5(12)13)8(18)21-10(9(19)20,2-6(14)15)3-7(16)17;7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h4,11H,1-3H2,(H,12,13)(H,14,15)(H,16,17)(H,19,20);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;;3*+2/p-6 Key: MIODSEIRCYRWJU-UHFFFAOYSA-H;
	SMILES C(C(C(=O)OC(CC(=O)[O-])(CC(=O)[O-])C(=O)[O-])O)C(=O)O.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Ca+2].[Ca+2].[Ca+2];
Properties
Chemical formula	(C6H7O7)x·(C4H5O5)y·(Ca2+)z
Molar mass	Variable
Appearance	White solid
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Calcium citrate malate is a water-soluble calcium supplement. It is the calcium salt of citric acid and malic acid with variable composition.

Calcium citrate malate's bioavailability stems from its water-solubility and its method of dissolution. When dissolved, it releases calcium ions and a calcium citrate complex. Calcium ions are absorbed directly into intestinal cells, and the citrate complex enters the body through paracellular absorption.

Calcium citrate malate is similar to calcium malate and other calcium salts. The European Food Safety Authority has concluded that calcium citrate malate is "slightly more bioavailable" than other forms of calcium supplementation.[2]

References

Calcium citrate malate at Jost Chemical
"Calcium citrate malate as source for calcium for use in foods for Particular Nutritional Uses and in foods for the general population (including food supplements)" (PDF). The EFSA Journal. 612: 1–24. 2007. doi:10.2903/j.efsa.2007.612Scientific Opinion of the Panel on Food Additives, Flavourings, Processing aids and Materials in Contact with food (AFC)

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[1] Calcium citrate malate at Jost Chemical

[2] "Calcium citrate malate as source for calcium for use in foods for Particular Nutritional Uses and in foods for the general population (including food supplements)" (PDF). The EFSA Journal. 612: 1–24. 2007. doi:10.2903/j.efsa.2007.612Scientific Opinion of the Panel on Food Additives, Flavourings, Processing aids and Materials in Contact with food (AFC)