Cardinals created by Pius II
5 March 1460
- Angelo Capranica, bishop of Rieti – cardinal priest of S. Croce in Gerusalemme (received the title on 26 March 1460), then cardinal bishop of Palestrina (11 December 1472), died 3 July 1478
- Berardo Eroli, bishop of Spoleto – cardinal priest of S. Sabina (received the title on 19 March 1460), then cardinal bishop of Sabina (23 May 1474), died 2 April 1479
- Niccolò Fortiguerra, bishop of Chieti – cardinal priest of S. Cecilia (received the title on 19 March 1460), died 21 December 1473
- Alessandro Oliva, O.E.S.A., prior general of his order – cardinal priest of S. Susanna (received the title on 19 March 1460), died 20 August 1463
- Francesco Nanni-Todeschini-Piccolomini, nephew of the Pope, administrator of the see of Siena – cardinal deacon of S. Eustachio (received the title on 26 March 1460), on 22 September 1503 became Pope Pius III, died 18 October 1503
- Burkhard Weisbriach, archbishop of Salzburg (created in pectore, published on 31 May 1462) – cardinal priest of SS. Nereo ed Achilleo (received the title on 31 May 1462), died 16 February 1466
18 December 1461
- Bartolomeo Roverella, archbishop of Ravenna – cardinal priest of S. Clemente (received the title on 26 January 1464), died 2 May 1476
- Jean Jouffroy, bishop of Arras – cardinal priest of SS. Silvestro e Martino (received the title on 16 March 1462), died in November 1473
- Jaime Cardona, bishop of Urgel – cardinal priest without the title, died 1 December 1466
- Louis d'Albret, bishop of Cahors – cardinal priest of SS. Marcellino e Pietro (received the title on 31 May 1462), died 4 September 1465
- Jacopo Piccolomini-Ammannati, bishop of Pavia – cardinal priest of S. Crisogono (received the title on 8 January 1462), then cardinal bishop of Frascati (17 August 1477), died 10 September 1479
- Francesco Gonzaga, protonotary apostolic – cardinal deacon of S. Maria Nuova (received the title on 2 April 1462), died 21 October 1483
31 May 1462
- Johann von Eych (d. 1464), Bishop of Eichstätt 1445-64
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